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 HBV mutation literature information.


  Characterization of Novel Hepatitis B Virus PreS/S-Gene Mutations in a Patient with Occult Hepatitis B Virus Infection.
 PMID: 27182775       2016       PloS one
Introduction: In this study, four mutations (sC124R, sC124Y, sK141E, and sD144A) strongly decreased the sensitivity of HBV detection in seven commercial HBsAg immunoassays.
Introduction: Recently, a novel vaccine escape S gene mutant (sP120Q+sD144A) was described.


  Overt and occult hepatitis B virus infection among treatment-naive HIV-infected patients in Brazil.
 PMID: 27061406       2016       Journal of medical virology
Abstract: Sequencing of the S gene revealed Y100C, T131N, and D144A mutations.


  Performance of HBsAg point-of-care tests for detection of diagnostic escape-variants in clinical samples.
 PMID: 26209374       2015       Journal of clinical virology
Abstract: The only false-negative result occurred using the Quick Profileassay with a virus harboring a D144A mutation.


  Impact of HBV genotypes A and D genetic variability on infection evolution.
 PMID: 25989376       2015       Infection, genetics and evolution
1Abstract: Mutations associated with immune-escape (T131N, D144A/E, G145K), amino acid polymorphisms in ""a determinant"" domain of S protein and mutations/deletions in preC/C region were found in isolates from acute and chronic hepatitis B cases."


  S gene mutants occurrence among hepatitis B carriers in malaysia.
 PMID: 25737728       2014       Hepatitis monthly
Discussion: The MHR region contains residues 99-169 of HBsAg and T/I126S, Q129H, G130N, S143L, D144A, G145A, and G145R were among the commonly reported mutations.


  Occult hepatitis B virus infection among blood donors in Colombia.
 PMID: 25471066       2014       Virology journal
Discussion: Thirteen MHR mutations (G119R, P120T, C124R, C124Y, I126S, Q129R, S136P, C139R, T140I, K141E, D144A, G145A, and G145R) were detected and functionally characterized in vitro and in vivo.


  Spontaneous HBsAg loss in Korean patients: relevance of viral genotypes, S gene mutations, and covalently closed circular DNA copy numbers.
 PMID: 25320728       2014       Clinical and molecular hepatology
Discussion: A mixture of D144G/D144A or combined D144E / G145R mutations were detected after hepatitis B immune globulin treatment.


  Molecular epidemiology and genotyping of hepatitis B virus of HBsAg-positive patients in Oman.
 PMID: 24835494       2014       PloS one
Discussion: However, in this domain (loop 2) the most prominent vaccine escape mutations sG145R and sD144E/A were not found in the patient collective.
Discussion: Other vaccine escape mutations, especially the G145R and D144E/A mutation, could not been detected.
Discussion: The best-described and stable vaccine escape mutations are the sG145R, sD144E/A, and sP120T mutations.


  Unique surface gene variants of hepatitis B virus isolated from patients in the Philippines.
 PMID: 24009186       2014       Journal of medical virology
Abstract: The amino acid substitution M133T which was associated with failure of HBsAg detection was found in one isolate (7%, 1/15), while the amino acid substitution D144A which was associated with vaccine escape was observed in one isolate (7%, 1/15).


  [Clinical evaluation of a newly developed high-sensitive detection of hepatitis B virus surface antigen by a semi-automated immune complex transfer chemiluminescent enzyme immunoassay].
 PMID: 24369590       2013       Rinsho byori. The Japanese journal of clinical pathology
Abstract: The sensitivity of wild type and HBsAg escape mutants (I126S, D144A, G145R) by ICT-CLEIA was 2- -5 to 2- -6 times higher than that of Architect HBsAg QT.



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