literature

HBV mutation literature information.

Pre-existing mutations related to tenofovir in chronic hepatitis B patients with long-term nucleos(t)ide analogue drugs treatment by ultra-deep pyrosequencing.

PMID: 27602500 2016 Oncotarget

Result: The frequencies of the rtI224V, rtS223A, rtD134E mutations slowly increased after 4 year of treatment.

Figure: The frequencies of the rtI224V, rtS223A, rtD134E mutations slowly increased after 4 years of treatment.

Characterization of antiviral resistance mutations among the Eastern Indian Hepatitis B virus infected population.

PMID: 23409946 2013 Virology journal

Introduction: Pretreatment mutations (such as T38A, Y124H, D134E, N139K/H, I224V, and R242A) were defined as amino acid substitutions that have been reported among NA-naive patients but their relationships with antiviral resistance development have not been clarified yet.

Table: D134E

Quasispecies and pre-existing drug-resistant mutations of hepatitis B virus in patients with chronic hepatitis B.

PMID: 23710315 2013 Gut and liver

Result: The predominant HBV quasispecies in patient 2 was R242A (36%), and the remaining were N76D+D134E (20%), D134E+R242A (17%), and D134E (13%).

Prevalence and significance of Hepatitis B reverse transcriptase mutants in different disease stages of untreated patients.

PMID: 22882650 2012 Liver international

Abstract: rtS106C, rtD134E/G/N/S and A-B interdomain mutations may be associated with necro-inflammation, immune response and cirrhosis development at ages older than 40.

Discussion: And rtD134E/G/N/S mutation could also generate the sI126N/V mutation in the S gene of HBV.

Discussion: And the rtS106C and rtD134E/G/N/S mutations may be associated with

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