Associations of pri-miR-34b/c and pre-miR-196a2 polymorphisms and their multiplicative interactions with hepatitis B virus mutations with hepatocellular carcinoma risk.
Result: The HBV mutations including T1674C/G, A1762T/G1764A, T1753V, C1653T, and G1896A in the EnhII/BCP/PC as well as preS deletion, preS1 start codon mutation, preS2 start codon mutation, C2875A, A3120G/T, C7A, and C76A in the preS region were significantly associated with an increased risk of HCC, while
Association of novel mutations and haplotypes in the preS region of hepatitis B virus with hepatocellular carcinoma.
PMID: 21104161
2010
Frontiers of medicine in China
Abstract: Multivariate regression analyses showed that C76A/T was a novel factor independently associated with an increased risk of HCC, as compared with those without HCC.