Discussion: Although we did not examine the infectious ability of the isolates with sC69*, infection of new hepatocytes through alternative secretion of the isolates, as evidenced via exosomes in our study, is expected even if the incomplete structure of envelop proteins does not support the infectivity.
Discussion: In conclusion, we herein show the selection of functionally relevant rtS78T/sC69* mutation in two HBV-infected patients with TDF/ETV combination therapy.
Discussion: In this regard, the emergence of rtS78T/sC69* mutation has been occasionally reported in the literature.
Virological Characteristics of Acute Hepatitis B in Eastern India: Critical Differences with Chronic Infection.
Result: It is noteworthy, that the C69stop codon mutation in the surface gene, the C1766T /T1768A mutation in the basal core promoter and the H94Y mutation in the x gene were found only in chronic patients.
Result: The C69stop codon mutation was undetectable in acute infection.
Discussion: Among them the C69stop codon mutation in the surface gene, the C1766T /T1768A mutation in the basal core promoter and the H94Y mutation in the x gene were found only in chro
Amino acid similarities and divergences in the small surface proteins of genotype C hepatitis B viruses between nucleos(t)ide analogue-naive and lamivudine-treated patients with chronic hepatitis B.
Abstract: Interestingly, another newly-identified truncation mutation sC69stop/rtS78T decreased from 7.91% (11/139) in NA-naive cohort to 2.70% (2/74) in LMV-treated one.
Identification of transforming hepatitis B virus S gene nonsense mutations derived from freely replicative viruses in hepatocellular carcinoma.
Discussion: Among the 11 HBV S gene truncation mutants we have identified (sL15*, sL21*, sS61*, sC69*, sL95*, sW156*, sW163*, sW172*, sW182*, sW196*, and sL216*) in HBV-related PMID: 24587360
2014
PloS one
Result: Additionally, two premature stop codon mutations, the C69* and the W182* mutation, were observed outside the MHL region in two isolates.
Hepatitis B viral surface mutations in patients with adefovir resistant chronic hepatitis B with A181T/V polymerase mutations.
PMID: 20119580
2010
Journal of Korean medical science
Result: In Group C, there was one case of each of the following mutations: G10stop, L15V, I28V, W36L, F41S, T47A, Q51L, N59H, C69stop, L87V, F93L, V96G, L97P, G102C, T131P, Y200F, and C221Y.
HBV mutation literature information.
PMID: 
2017
Journal of hepatology
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