Introduction: Mutations at T53C, PreS deletions, PreS2 start codon, C7A, A2962G, C2964A and C3116T in the PreS region have been proved that significantly increase risk of HCC.
Complete genome sequencing and clinical analysis of intrahepatic hepatitis B virus cccDNA from HCC.
Abstract: Finally, significantly higher levels of preoperative alpha-fetoprotein were observed in patients harboring the G1078T, C1653T, G1727A, C1913A, T1978C, or C3116T mutations at the cccDNA level.
Molecular characterization of hepatitis B virus in Vietnam.
Method: The preS2/S1 sequences were analyzed for preS1 deletion, preS1 mutations (A2962G, C3026A/T, C2964A, and C3116T), preS2 start codon deletion, and preS2 mutations (T31C, T53C, A162G, and T531C/G).
Phosphatase and tensin homologue genetic polymorphisms and their interactions with viral mutations on the risk of hepatocellular carcinoma.
Discussion: The interactions of rs2299939 polymorphism with A3054T mutation or rs1234213 polymorphism with C3116T mutation significantly increased the risk of HCC in male HBV-infected subjects; whereas the interaction of rs2299939 polymorphism with C3116T mutation significantly decreased the risk of HCC.
Discussion: Thus, the effects of important HCC-related HBV mutations such as A3054T and C3116T on HCC susceptibility can be moderated by host genetic susceptibility such as PTEN polymorphisms.
Effects of antiviral therapy on the recurrence of hepatocellular carcinoma after curative resection or liver transplantation.
Introduction: C1653T, T1753V, A1762T/G1764A, T1674C/G, C1766T/T1768A, T53C, preS2 start codon mutation, preS1 deletion, C2964A, A2962G, C3116T, C7A, and their combinations are HBV mutations that are significantly associated with an increased risk of HCC occurrence.
Significant association of different preS mutations with hepatitis B-related cirrhosis or hepatocellular carcinoma.
Abstract: CONCLUSIONS: C2964A, C3116T, and C7A are novel markers independently associated with an increased risk of HCC, while A2964C and T3116C are novel markers independently associated with an increased risk of cirrhosis.
Abstract: Multivariate regression analyses showed that C2964A, C3116T, and C7A were novel factors associated with HCC compared with those without HCC, whereas A2964C and T3116C were independently as
Association of novel mutations and haplotypes in the preS region of hepatitis B virus with hepatocellular carcinoma.
PMID: 21104161
2010
Frontiers of medicine in China
Abstract: As compared with the HBV-infected subjects without HCC, C2875T, G2946C, A3054C, C3060A, T3066C, C3116T, A3120C, G3191A, A1C, C7A, C10A, A31C, C76T, G105C, and G147C in both genotypes were significantly associated with increased risks of HCC.
HBV mutation literature information.
PMID: 
2022
PloS one
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