Combining the HBcrAg decline and HBV mutations predicts spontaneous HBeAg seroconversion in chronic hepatitis B patients during the immune clearance phase.
Abstract: Baseline A1574T, G1862A, G1896A, and C1913G mutations and HBcrAg levels with a sharp decrease at Week 28 were associated with spontaneous HBeAg seroconversion.
Abstract: The mutation frequencies of A1574T (51.11% vs. 18.18%, p = 0.001), G1862A (30.00% vs. 13.03%, p = 0.001), G1896A (27.22% vs. 5.45%, p = 0.001), and C1913G (32.78% vs. 12.73%, p = 0.001) in Group A were significantly higher than Group B.
Hepatitis B virus precore/core region mutations and genotypes among hepatitis B virus chronic carriers in South-Eastern, Nigeria.
PMID: 33708042
2021
International journal of health sciences
Discussion: Furthermore, the core gene mutations previously reported to be associated with liver disease progression in chronic patients and particularly in HCC patients such as C1913A/G, C1914G, and G1915T were not identified in any of the sequences from this study.
Pre-S/Surface and Core Promoter/Precore Mutations in Chronic Hepatitis B Patients with Severe Acute Exacerbation.
PMID: 30835025
2019
Digestive diseases and sciences
Abstract: Multivariate analysis showed that the independent factors for SAE were V14G/A and L21S in surface genes, codons 109-119 deletions in pre-S1 genes, M1V/T/I in pre-S2 genes, and C1766T/T1768A and C1913A/G mutations in BCP/PC genes.
Clinical and virological implications of A1846T and C1913A/G mutations of hepatitis B virus genome in severe liver diseases.
PMID: 29322851
2018
Scandinavian journal of gastroenterology
Abstract: RESULTS: There was significant difference in the detection rates of A1846T (30.82%, 40.41% and 55.48%, respectively) and C1913A/G (15.52%, 28.77%, and 35.62%, respectively) among patients with CHB-M, those with CHB-S, and those with ACLF (p < .01).
Abstract: This study aimed to observe the clinical and virological implications of the A1846T and C1913A/G mutations of HBV genome in the development and treatment outcome of severe liver diseases, which has not been previously determined.
New point mutations in surface and core genes of hepatitis B virus associated with acute on chronic liver failure identified by complete genomic sequencing.
Result: Rather than a single mutation, combinations with any 2 or more of T216C, G1896A, C1913A/G and A2159G/C were significantly associated with the development of ACLF compared with non-ACLF (78.8% vs.
Discussion: Multivariate regression analysis showed that T216C, G1896A, C1913A/G and A2159G/C mutations were independent risk factors for ACLF cases.
Discussion: Of these seven mutations, A1846T/G, G1896A and C1913A/G were
Hepatitis B virus genotype B and mutations in basal core promoter and pre-core/core genes associated with acute-on-chronic liver failure: a multicenter cross-sectional study in China.
Abstract: The A1762T/G1764A, A1846T and G1896A mutations were significantly more common in HB-ACLF patients infected with either genotype B or C as compared with CHB-M, whereas the C1913A/G and A2159G mutations were more associated with HB-ACLF in genotype C patients.
Clinical and virological implications of A1846T and C1913A/G mutations of hepatitis B virus genome in severe liver diseases.
Result: In genotype C infection, a statistically higher prevalence (P < 0.05) in the occurrence of mutations was observed at A1846T and C1913A/G in patients with ACLF-CHB and ACLF-LC than those with CHB and LC, respectively.
Figure: Possible influences of A1846T and C1913A/G mutations on Figure: The C1913A/G mutation causes a substitution of the fifth amino acid in core protein from proline to threonine or alanine.
HBV mutation literature information.
PMID: 
2022
Journal of medical virology
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