Hepatitis B virus precore/core region mutations and genotypes among hepatitis B virus chronic carriers in South-Eastern, Nigeria.
PMID: 33708042
2021
International journal of health sciences
Abstract: Other HBV precore region mutations that were detected include: G1899A, T1846A, G1862C, G1888A, T1821C, C1826T, A1827C, A1850T, C1858T, precore start codon Kozak sequence mutations and some novel core region mutations such as G/A1951T and G1957A.
Precore and Basal Core Promoter Hepatitis B Virus (HBV) Variants Are Present From a Young Age and Differ Across HBV Genotypes.
Abstract: CONCLUSIONS: PC variants can be present in HBV genotype A and are usually associated with C1858T, which preserves the pregenome encapsidation sequence.
Abstract: Seventeen of 20 participants with genotype A and PC had a compensatory C1858T mutation.
Molecular characteristics of HBV infection among blood donors tested HBsAg reactive in a single ELISA test in southern China.
Abstract: The C1505A mutation in X region, T1753V and A1762T/G1764A mutations in the basal core promoter region and C1858T in precore (PC) region were frequent and only detected in patients with ALD (28.9, 40, 73.5 and 17.6%, respectively), whereas the G1896A mutation in the PC region was frequently detected in HBV carriers.
Analysis of HBV basal core promoter/precore gene variability in patients with HBV drug resistance and HIV co-infection in Northwest Ethiopia.
Discussion: In regard to PC mutations, although the overall mutant variants were found to be proportional among HIV co-infected and HBV mono-infected groups, none of the classical PC mutations (A1814C/C1816T, C1858T, G1862T and G1896) also associated with 3TC/ETV resistance gene mutations associated with the YMDD RT motif during HIV co-infection.
Discussion: Interestingly, the premature stop codon (G1896A) that is known to abolish the synthesis of HBeAg in particular with C1858T was
Basal core promoter and precore mutations among hepatitis B virus circulating in Brazil and its association with severe forms of hepatic diseases.
PMID: 28902288
2017
Memorias do Instituto Oswaldo Cruz
Result: In this viral sequence, as expected, the presence of the C1858T mutation was noted.
Result: The presence of T in position 1858 is common among HBV genotype D and uncommon among HBV genotype A, so finding this type of mutation in HBV genotype A sequences is not expected unless the virus has the C1858T mutation .
G1896A Precore Mutation and Association With HBeAg Status, Genotype and Clinical Status in Patients With Chronic Hepatitis B.
Abstract: RESULTS: The most commonly observed mutation in the precore region was C1858T with 64.5% prevalence.
Table: C1858T
Discussion: From the analysis of the Malaysian HBV sequences, most isolates were found to confer C1858T mutation in the precore region.
Discussion: Genotype predominance was not observed in subjects with C1858T mutation as it was equally distributed among HBV B and C genotypes and found in two of the D genotype.
Discussion: These mutations include a change in DNA bases from guanine to adenine at position 1896 (G1896A), and from cytosine to thymine at position 1858 (C1858T) of the viral genome.
Discussion: When
Molecular characterization of HBV strains circulating among the treatment-naive HIV/HBV co-infected patients of eastern India.
Result: Similarly, the precore stop codon mutation (G1896A) occurred in 13 isolates (13/59, 22%) with all harboring the C1858T mutation and in 4 cases it occurred along with G1899A mutation.
Figure: The frequency of the G1896A precore mutation was higher compared to the BCP double mutations in our settings with majority of the strains harboring the C1858T mutation.
Mutation profiling of the hepatitis B virus strains circulating in North Indian population.
Abstract: Additionally, several mutations were found in the BCP region with the following incidence rate; C1653 T (8.6%), A1752 G (10.8%),1762 AGG--TGA 1764 (26.9%), C1766T(2.2%),T1768 A (10.8%), C1858 T (64.5%), G1896 A (25.8%).
Result: The most common mutation observed was precore mutation C1858 T which comprised 64.5% of the sequencedisolates.
HBV mutation literature information.
PMID: 
2021
International journal of health sciences
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