Abstract: The mutation rates of G1721a, C1856t and T1858c of genotype C samples were 30.9%, 16.2% and 30.9%, respectively, while the mutation rates of genotype B samples were 0.4%, 0, 0, P < 0.001, respectively.
Mutations of Basal core promoter and precore regions in hepatitis B virus genotypes B and C.
Result: Similarly, most of the C1856T mutations from genotype C sequences of the HBV-infected children were also detected in combined mutation forms (G1721A/A1775G/C1856T/T1858C, 8/9, 88.9%).
Table: C1856T
Discussion: In addition, other combined mutation types such as C1856T/T1858C/G1721A and G1721A/G1757A/A1775G/T1858C were also exclusively detected in children with genotype C infection, while the clinical characteristi
Variability in the precore and core promoter region of the hepatitis B virus genome.
Abstract: A rare double mutation (C1857T together with G1897A) was observed, and C1856T was found together with the emerging G1898A mutation, which itself was found to be more widespread geographically than previously described.
Two subtypes (subgenotypes) of hepatitis B virus genotype C: A novel subtyping assay based on restriction fragment length polymorphism.
Abstract: Some specific mutations were detected in the encapsidation signal; precore stop mutation (A1896), accompanied by a C-to-T substitution at nt 1858, was found in HBV/Ce strains, and another precore mutation (A1898), accompanied by a C-to-T mutation at nt 1856, was found in HBV/Cs.
[The prevalence of hepatitis B virus precore mutant isolated from asymptomatic carriers in Guangxi].
PMID: 12667359
2002
Zhonghua liu xing bing xue za zhi
Abstract: Both mutation at nt1856 (C-->T) and nt1858 (T-->C) could be seen in sample 734.
Mutations in the pre-core region of hepatitis B virus serve to enhance the stability of the secondary structure of the pre-genome encapsidation signal.
Abstract: Four major missense/nonsense mutations (M) were found: (M1) C-->T at nucleotide position 1856, Pro-->Ser at codon 15; (M2) G-->A at position 1896, Trp-->stop at codon 28; (M3) G-->A at position 1898, Gly-->Ser at codon 29; and (M4) G-->A at position 1899, Gly-->Asp at codon 29.
Detection of precore hepatitis B virus mutants in asymptomatic HBsAg-positive family members.
Abstract: We previously reported two novel mutations: M1 (C-to-T change at nucleotide 1856 [proser at codon 15]) and M3 (G-to-A change at nucleotide 1898 [gly-ser at codon 29]) in addition to two well-described mutations: M2 (G-to-A change at nucleotide 1896 [trp-stop at codon 28]); and M4 (G-to-A change at nucleotide 1899 [gly-asp at codon 29]) in Chinese patients.
HBV mutation literature information.
PMID: 
2020
Zhonghua gan zang bing za zhi
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