literature

HBV mutation literature information.

Analysis of HBV basal core promoter/precore gene variability in patients with HBV drug resistance and HIV co-infection in Northwest Ethiopia.

PMID: 29408943 2018 PloS one

Result: The Kozak sequence mutants (nt 1809-1812) with a prevalence of 51.7% (74) includes T1809G (32.9%), C1810A/T (2.8%), A1811C (9.8%) and T1812C (38.5%) (Table 2).

Figure: *The translational or the Kozak sequence mutants include T1809G, C1810A/T, A1811C and T1812C.

Hepatitis B virus subgenotype C2- and B2-associated mutation patterns may be responsible for liver cirrhosis and hepatocellular carcinoma, respectively.

PMID: 23903686 2013 Brazilian journal of medical and biological research

Result: When LC patients were the control, HBV subgenotype B2-associated mutation patterns (C1810T, A1846T, G1862T, and G1896A) close to the precore region were independent risk factors for HCC.

Discussion: The C1810T and

Discussion: The C1810T, A1846T, G1862T, and G1896A mutations most likely result in crude expression of HBeAg and accumulation of the HBeAg precursor in the endoplasmic reticulum/Golgi apparatus of the cell.

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