Abstract: Additionally, several mutations were found in the BCP region with the following incidence rate; C1653 T (8.6%), A1752 G (10.8%),1762 AGG--TGA 1764 (26.9%), C1766T(2.2%),T1768 A (10.8%), C1858 T (64.5%), G1896 A (25.8%).
Result: Among the basal core promoter mutations, A1762T-G1764A double mutation was present in 26.9%, C1653T in 8.6%, A1752G in 10.8% and C1766T in 2.2% of the isolates.
Novel natural mutations in the hepatitis B virus reverse transcriptase domain associated with hepatocellular carcinoma.
Introduction: Over the past few years, we defined that a high prevalence of the HBV C1 genotype, pre-S deletion and pre-S2 start codon mutation, C1653T, T1753A/G, C1766T, and T1768A mutations in the BCP/EnhII region, and A2159G, A2189C, and G2203W in the core gene are associated with HCC in Qidong.
Hepatitis B virus subgenotype A1 predominates in liver disease patients from Kerala, India.
PMID: 24409056
2013
World journal of gastroenterology
Abstract: Mutation C1766T/T1768A was significantly associated with genotype A (P = 0.05) and HCC (P = 0.03).
Association of Hepatitis B Virus Mutations of A1846T and C1913A/G With Acute-on-Chronic Liver Failure Development From Different Underlying Chronic Liver Diseases.
Result: In addition, since BCP/PC mutations of T1754G, T1758C, C1766T, T1768A, G1862T, and T1858C were observed only in 7, 5, 7, 4, 1, and 4 of ACLF patients, respectively, these mutations were not included in further analysis.
Precore/core promoter mutations and hepatitis B virus genotype in hepatitis B and C dually infected patients treated with interferon-based therapy.
Abstract: Based on Cox proportional hazards model, young age (hazard ratio (HR)=0.952, P=0.001), sustained virological response to HCV (HR=4.638, P=0.044), C1766T mutation (HR=5.216, P=0.003) and A1846T mutation (HR=2.332, P=0.031) correlated with HBV DNA reactivation (>=2000IU/ml) after therapy.
A multicentre molecular analysis of hepatitis B and blood-borne virus coinfections in Viet Nam.
Discussion: Genetic mutations and deletions in the pre-S and basal core promoter regions of the HBV genome including T1753V, A1762T, G1764A, and C1766T have been associated with more severe liver disease and the development of HCC.
Variability in the precore and core promoter regions of HBV strains in Morocco: characterization and impact on liver disease progression.
Result: In addition, patients harboring strains with G1899A, C1653T, T1753V, A1762T/G1764A and C1766T/T1768A mutations were significantly older than those without these mutations (p<=0.01).
Result: In the BCP, G1764A was the most frequent (72/186, 3
Result: With regard to the CP mutations, six were associated with the clinical status of patients: C1653T, G1764A, A1762T, T1753V, C1766T and T1768A.
Effects of antiviral therapy on the recurrence of hepatocellular carcinoma after curative resection or liver transplantation.
Introduction: C1653T, T1753V, A1762T/G1764A, T1674C/G, C1766T/T1768A, T53C, preS2 start codon mutation, preS1 deletion, C2964A, A2962G, C3116T, C7A, and their combinations are HBV mutations that are significantly associated with an increased risk of HCC occurrence.
Prevalence of hepatitis B genotype and viral basic core promoter and precore mutations among teenagers in Macao: relationship with hepatocellular carcinoma development.
PMID: 21950207
2011
British journal of biomedical science
Abstract: The BCP/PreC mutations A1762T, G1764A, G1896A and C1766T were identified in 2.9-11.7% of subjects.
Association between the various mutations in viral core promoter region to different stages of hepatitis B, ranging of asymptomatic carrier state to hepatocellular carcinoma.
PMID: 20959817
2011
The American journal of gastroenterology
Abstract: C1673T, A1726C, A1727T, C1730G, C1766T, T1768A, C1773T, and C1799G in genotype C were significantly associated with cirrhosis compared with the CHB patients, whereas these mutations were inversely associated with HCC compared with the cirrhosis patients.
HBV mutation literature information.
PMID: 
2014
Hepatitis monthly
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