A case-control study on sequence variations in the enhancer II/core promoter/precore and X genes of hepatitis B virus in patients with hepatocellular carcinoma.
Abstract: No significant difference between groups was found with respect to G1613A, C1653T, C1766T/T1768A, A1846T/C, T1858C, and G1896A mutations.
Hepatitis B virus genotype and basal core promoter/precore mutations are associated with hepatitis B-related acute-on-chronic liver failure without pre-existing liver cirrhosis.
Introduction: In addition, single mutations including the T1753V (C/A/G), C1766T, T1768A, G1862T and G1899A in the BCP/PC region have been reported to be associated with increased HBV replication capacity and/or reduced HBeAg expression in vitro, and in some cases associated with ALF in the clinic.
Table: C1766T
Discussion: Therefore, we analyzed two triple BCP mutational patterns T1753V/A1762T/G1764A and A1762T/
Associations between hepatitis B virus mutations and the risk of hepatocellular carcinoma: a meta-analysis.
PMID: 19574418
2009
Journal of the National Cancer Institute
Table: C1766T
Genetic dissection of naturally occurring basal core promoter mutations of hepatitis B virus reveals a silent phenotype in the overlapping X gene.
PMID: 19439550
2009
The Journal of general virology
Abstract: During chronic hepatitis B virus (HBV) infection, double substitution mutations in the basal core promoter (BCP) region frequently emerge that include A1762T/G1764A and the neighbouring C1766T/T1768A mutations, here termed BCP1 and BCP2, respectively.
Chimeric constructs between two hepatitis B virus genomes confirm transcriptional impact of core promoter mutations and reveal multiple effects of core gene mutations.
Abstract: Introduction of its T1753C, A1762T, G1764A, and C1766T core promoter mutations into the 2A genome greatly enhanced genome replication and suppressed HBeAg expression.
Discussion: The high replication capacity was mapped to nucleotides 1574-1986, where 7 Discussion: Thus, clone 4B contains a combination of T1753C, A1762T, G1764A, and C1766T mutations in the core promoter and replicated about 10-20 times more efficiently than clone 2A with a wild-type core promoter sequence.
Effect of basal core promoter and pre-core mutations on hepatitis B virus replication.
PMID: 18343830
2008
The Journal of general virology
Abstract: Substitutions A1762T/G1764A and T1753C, C1766T and T1768A in the BCP region, and G1896A and G1899A in the pre-C region, were examined either alone or in combination, using a common genetic background.
Genome replication, virion secretion, and e antigen expression of naturally occurring hepatitis B virus core promoter mutants.
Abstract: A much higher replication capacity was reported for a naturally occurring core promoter mutant implicated in the outbreak of fulminant hepatitis, which was caused by the neighboring C1766T/T1768A mutations instead.
Abstract: All had 1762/1764 mutations and an additional substitution at position 1753 (T to C), at position 1766 (C to T), or both.
Hepatitis B virus core promoter mutations in children with multiple anti-HBe/HBeAg reactivations result in enhanced promoter activity.
Abstract: In both patients, rare mutations were found in the BCP at nucleotides 1764(G-->T)/1766(C-->G) and 1766(C-->T)/1768(T-->A) in case 1 and 2, respectively.
HBV mutation literature information.
PMID: 
2010
Hepatology international
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