Prevalence, genotype distribution and mutations of hepatitis B virus and the associated risk factors among pregnant women residing in the northern shores of Persian Gulf, Iran.
Result: T1753A, A1761C, G1764T/A, C1766G/T, and C1773T mutations were detected in the BCP region.
Result: Of these, T1753A and A1761C mutations were detected in one sample (HB55); and G1764T/A, C1766G/T, and C1773T mutations were detected in two samples (HB35 and HB55).
Hepatitis B virus drug resistance mutations in HIV/HBV co-infected children in Windhoek, Namibia.
Result: Additional substitutions were observed in the upper regulatory region (URR) and BCP regions: patient 2C carried the HBV URR mutant G1728A and BCP mutant G1764T/C1766G, and HBV from patients 6C and 7C carried BCP T1768A and URR C1678T mutants, respectively.
Discussion: The G1764T/C1766G BCP double mutation is enriched among cirrhotic patients, and combined core mutations are more common in children with liver cirrhosis.
Discussion: Though t
Nucleotide Substitutions in Hepatitis B Viruses Derived from Chronic HBV Patients.
PMID: 31308922
2019
Mediterranean journal of hematology and infectious diseases
Discussion: It has been suggested that the G1764T/C1766G mutant creates a new binding site for the hepatoc
Discussion: More extensive research work is needed to explore the tendency to either A1762T/G1764A or C1766G/G1764T.
Discussion: None of the patients with G1764T/C1766G mutation carried A1762T/G1764A substitution.
Discussion: When there is G1757A, the C1766G/G1764T double mutant is more efficient than the A1762T/G1764A mutation.
Hepatitis B virus sequencing and liver fibrosis evaluation in HIV/HBV co-infected Nigerians.
PMID: 28376292
2017
Tropical medicine & international health
Result: Six patients had C1766G and four patients had T1753C.
Molecular characterization of hepatitis B virus in Vietnam.
Result: T1753C, G1757A, A1762T, G1764A and C1766G mutations were identified in 11.1% (5/135), 7.4% (10/137), 25.9%% (35/135), 24.4% (33.135) and 2.2% (3/135) of the isolates and A1762T and G1764 T mut
Result: BCP/preC/core gene mutation: BCP mutations at T1753C, G1757A, A1762T, G1764 T and C1766G were analyzed and 30.4% (41/135) of all isolates including 78.4% (29/37) of the C1 isolates had at least one mutation.
Variability in the precore and core promoter regions of HBV strains in Morocco: characterization and impact on liver disease progression.
Result: In the BCP, G1764A was the most frequent (72/186, 38.7%), followed by A1762T (59/186, 31.7%), T1753V (28.5%), A1757G (21.5%), C1766G (48/186, 26%), C1766T (41/186, 22%), G1764T (35/186, 18.8%) and T1768A (29/186, 15.6%).
Result: The mutations T1636G, A1757G and G1764T/C1766G were exclusively found in genotype D strains.
Table: C1766G
Frequency and clinical significance of core promoter and precore region mutations in Tunisian patients infected chronically with hepatitis B.
Abstract: High DNA levels were associated with G1899A or G1764T/C-C1766G-C1799G and advanced liver disease with mutations at positions 1762, 1764 and/or 1899 alone or in double or triple mutations.
Full genome characterization of hepatitis B virus strains from blood donors in Iran.
Abstract: The double mutations A1762T/G1764A and G1764T/C1766G were found in 20.7% and 24.1% of the strains, respectively.
Association of core promoter mutations with viral breakthrough in chronic hepatitis B patients on long-term lamivudine therapy.
PMID: 16928212
2006
Journal of gastroenterology and hepatology
Abstract: Core promoter mutations were seen in five of eight (62.5%) and in six of nine (66.6%); classic double mutations (A1762T/G1764A) of core promoter region were detected in two and three patients and novel double mutations of core promoter (G1764T/C1766G) in one patient each of group Ia and Ib patients, respectively.
Hepatitis B virus core promoter mutations in children with multiple anti-HBe/HBeAg reactivations result in enhanced promoter activity.
Abstract: In both patients, rare mutations were found in the BCP at nucleotides 1764(G-->T)/1766(C-->G) and 1766(C-->T)/1768(T-->A) in case 1 and 2, respectively.
HBV mutation literature information.
PMID: 
2022
PloS one
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