literature

HBV mutation literature information.

The Occurrence of rtA194T Mutant After Long-Term Lamivudine Monotherapy Remains Sensitive to Tenofovir Disoproxil Fumarate: A Case Report.

PMID: 33758517 2021 Infection and drug resistance

Discussion: However, G1896A or A1762T/G1764A mutations were not found in this patient with genotype C HBV by DNA sequencing, while A1727T, C1730G and C1799G mutations were found in BCP region, which were reported to be associated significantly with cirrhosis.

Hepatitis B virus mutations, expression quantitative trait loci for PTPN12, and their interactions in hepatocellular carcinoma.

PMID: 27075395 2016 Cancer medicine

Result: Of those 19 hotspot mutations, C1653T, T1674C/G, A1703G, G1719T, T1727A/G, T1753C, A1762T, G1764A, G1799C, G1899A, G1915A/C, and C1969T were significantly associated with an increased risk of HCC, whereas C1673T, A1726C, C1730G, and A1752G were significantly associated with a reduced risk of

PMID: 25881591 2015 Chinese medical journal

Abstract: rs1234220 C allele was significantly associated with increased frequencies of HCC-risk A1652G, C1673T, and C1730G mutations in genotype B HBV-infected subjects.

Result: It was found that the variant genotype (TC) of rs1234220 was significantly associated with increased frequencies of HBV mutations A1652G (AOR = 4.16, 95% CI = 1.64-10.55), C1673T (AOR = 2.40, 95% CI = 1.02-5.66), and C1730G (AOR = 2.34, 95% CI = 1.02-5.39) in genotype B HBV-infected subjects.

Discussion: We also found that rs1234220 variant genotype was significantly associated with increased frequencies of HBV mutations

Hepatitis B virus genotype, mutations, human leukocyte antigen polymorphisms and their interactions in hepatocellular carcinoma: a multi-centre case-control study.

PMID: 26568165 2015 Scientific reports

Result: The results indicated that the HBV mutation C1730G was correlated with T1727A/G and G1799C (r2 > 0.800).

Result: We then used a conditional logistic regression analysis to test the independence of these hotspot mutations and found that the effects of C1653T, C1673T, T1674C/G, C1730G, A1752G, T1753C, A1762T<

Discussion: In addition, the effect of C1730G was reversed from a protective effect (adjusted OR = 0.18, 95% CI = 0.15-0.22) to a risk effect with borderline significance (adjusted OR = 2.07, 95% CI = 1.02-4.20) after being conditionally adjusted by the other mutations.

Significance of mutations in hepatitis B virus X gene for the pathogenesis of HB-associated glomerulonephritis.

PMID: 25283864 2014 Acta virologica

Abstract: In HBV-GN patients, missense nucleotide mutations of C1653T, A1726C, A1727T, C1730G, T1753C, A1762T, and G1764A were detected in 84% of subjects, all located in the trans-acting regulatory region of the X gene.

Associations of pri-miR-34b/c and pre-miR-196a2 polymorphisms and their multiplicative interactions with hepatitis B virus mutations with hepatocellular carcinoma risk.

PMID: 23516510 2013 PloS one

Abstract: In multivariate regression analyses, rs4938723 in dominant model increased HCC risk (AOR = 1.62, 95% CI = 1.05-2.49), whereas its multiplicative interaction with C1730G, a HBV mutation inversely associated with HCC risk, reduced HCC risk (AOR = 0.34, 95% CI = 0.15-0.81); rs11614913 strengthened the G1896A effect but attenuated the A3120G/T effect on HCC risk.

Result: In the study subjects with the data of HBV mutations in the EnhII/BCP/PC region, pri-miR-34b/c rs4938723 in dominant genetic model was significantly associated wi

Association between the various mutations in viral core promoter region to different stages of hepatitis B, ranging of asymptomatic carrier state to hepatocellular carcinoma.

PMID: 20959817 2011 The American journal of gastroenterology

Abstract: C1673T, A1726C, A1727T, C1730G, C1766T, T1768A, C1773T, and C1799G in genotype C were significantly associated with cirrhosis compared with the

Abstract: CONCLUSIONS: C1673T, A1726C, A1727T, C1730G, C1766T, T1768A, C1773T, and C1799G in genotype C are specific for cirrhosis.

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