literature

HBV mutation literature information.

[Monitoring by high-sensitivity HBV DNA assay during treatment in chronic hepatitis B e antigen negative patients].

PMID: 29804376 2018 Zhonghua gan zang bing za zhi

Abstract: After treatment, the detection rate of the above mutation sites decreased, but C1653T, C1673T and G1899A were not detected.

Abstract: Patients C, B, C, B, and C were examined for C1673T, G1896, G1858, G1899A.

Hepatitis B virus mutations, expression quantitative trait loci for PTPN12, and their interactions in hepatocellular carcinoma.

PMID: 27075395 2016 Cancer medicine

Result: Of those 19 hotspot mutations, C1653T, T1674C/G, A1703G, G1719T, T1727A/G, T1753C, A1762T, G1764A, G1799C, G1899A, G1915A/C, and C1969T were significantly associated with an increased risk of HCC, whereas C1673T, A1726C, C1730G, and A1752G were significantly associated with a reduced risk of

PMID: 25881591 2015 Chinese medical journal

Discussion: It is reasonable to speculate that rs1234220 var

Discussion: The effect of rs1234220 variant genotypes on HCC risk is only observed in genotype B HBV-infected subjects, possibly via facilitating the immune selection of A1652G, C1673T, and C1730G, the three HCC-risk mutations in genotype B HBV-infected subjects.

Discussion: We also found that rs1234220 variant genotype was significantly associated with increased frequencies of HBV mutations A1652G, C1673T, and C1730G in genotype B HBV-infected subjects.

Hepatitis B virus genotype, mutations, human leukocyte antigen polymorphisms and their interactions in hepatocellular carcinoma: a multi-centre case-control study.

PMID: 26568165 2015 Scientific reports

Method: A risk prediction model to classify the HCC cases and controls was constructed according to the following steps: (1) Prediction factor selection: HBV genotype, the 11 independent HCC-related mutations (C1653T, C1673T, T1674C/G, C1730G, A1752G, T1753C, A1762T, G1764A, G1899A, G1915A/C and C1969T), the HLA SNPs (rs9272105 and rs9275319), the HCC-related multiplicative interactions (rs9272105 with the HBV genotype,

Impacts of human leukocyte antigen DQ genetic polymorphisms and their interactions with hepatitis B virus mutations on the risks of viral persistence, liver cirrhosis, and hepatocellular carcinoma.

PMID: 25281206 2014 Infection, genetics and evolution

Abstract: The interaction of rs2856718 AG+GG genotype with T1753V, a HCC-risk mutation, significantly reduced LC risk, with an OR of 0.26 (95% CI, 0.09-0.78); whereas the interaction of rs2856718 AG genotype with C1673T, a LC-risk mutation, significantly increased HCC risk, with an OR of 2.80 (95% CI, 1.02-7.66) in genotype C HBV-infected subjects.

[Significance of the double mutations of C1673T/C1799G in HBV C promoter].

PMID: 23547448 2012 Zhonghua shi yan he lin chuang bing du xue za zhi

Abstract: C1673T/C1799G double mutations in Ba were determined in 106 (96. 4%) samples, which was significantly higher than in C1 (14.3%) and C2 (12.5%) subgenotype (P < 0.0001).

Abstract: CONCLUSION: In Ba subgenotype, double mutations of C1673T/C1799G is much popular than in C1 and C2; the mutation has no effect on HBV replication, and may not be associated with the outcome of chronic HBV infection.

Abstract: OBJECTIVE: To explore the biological and clinical significance of the double mutations of C1673T/C1799G in HBV C promoter (CP).

Association between the various mutations in viral core promoter region to different stages of hepatitis B, ranging of asymptomatic carrier state to hepatocellular carcinoma.

PMID: 20959817 2011 The American journal of gastroenterology

Abstract: C1673T, A1726C, A1727T, C1730G, C1766T, T1768A, C1773T, and C1799G in genotype C were significantly associated with cirrhosis compared with the

Abstract: CONCLUSIONS: C1673T, A1726C, A1727T, C1730G, C1766T, T1768A, C1773T, and C1799G in genotype C are specific for cirrhosis.

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