Association between the various mutations in viral core promoter region to different stages of hepatitis B, ranging of asymptomatic carrier state to hepatocellular carcinoma.
PMID: 20959817
2011
The American journal of gastroenterology
Abstract: T1674C/G, C1653T, and T1753V were specific for HCC.
Abstract: Age, abnormal ALT, HBV DNA (>=10(4) copies/ml), genotype C, C1653T, T1674C/G, T1753V, and A1762T/G1764A were independently associated with HCC compared with those without HCC.
Hepatitis B virus gene C1653T polymorphism mutation and hepatocellular carcinoma risk: an updated meta-analysis.
Abstract: A comparison of the nucleotide sequences of the HBV genome between HCC group 1 and non-HCC group 1 revealed that the prevalence of G1613A and C1653T mutations in the core promoter region was significantly higher in the HCC group.
Abstract: CONCLUSIONS: G1613A and C1653T double mutations were frequently found in patients with HCC.
Result: A C-to-T mutation at nucleotide 1653 occurred in 45% of HCC group 1 and 19% of non- PMID: 21490166
2011
Clinical and vaccine immunology
Abstract: The hepatitis B virus (HBV) PreS mutations C1653T, T1753V, and A1762T/G1764A were reported as a strong risk factor of hepatocellular carcinoma (HCC) in a meta-analysis.
Association between Hepatitis B Virus X Gene Mutations and Clinical Status in Patients with Chronic Hepatitis B Infection.
Abstract: RESULTS: Each of the mutations G1386M, C1485T, C1653T, T1753V, A1762T, and G1764A was significantly associated with the patient's clinical status.
Abstract: Specific X gene mutations (G1386M, C1653T, and A1762T/G1764A) were more prevalent in patients with liver cirrhosis and HCC than in chronic hepatitis patients (p<0.005 for all).
Distribution and hepatocellular carcinoma-related viral properties of hepatitis B virus genotypes in Mainland China: a community-based study.
PMID: 20160279
2010
Cancer epidemiology, biomarkers & prevention
Abstract: A1762T/G1764A, T1753V, C1653T, and G1896A, except PreS deletion, consecutively increased with increasing age.
A case-control study on sequence variations in the enhancer II/core promoter/precore and X genes of hepatitis B virus in patients with hepatocellular carcinoma.
Abstract: No significant difference between groups was found with respect to G1613A, C1653T, C1766T/T1768A, A1846T/C, T1858C, and G1896A mutations.
Comparison study on the complete sequence of hepatitis B virus identifies new mutations in core gene associated with hepatocellular carcinoma.
PMID: 20699378
2010
Cancer epidemiology, biomarkers & prevention
Abstract: RESULTS: The pre-S deletion and 12 point mutations, namely, the pre-S2 start codon mutation, T53C in the pre-S2 gene, T766A in the S gene, G1613A, C1653T, A1762T, G1764A in the X gene, and G1899A, C2002T, A2159G, A2189C, and G2203W (A or T) in the pre-C/C gene, showed close associations with
Clinical relevance and public health significance of hepatitis B virus genomic variations.
PMID: 19998495
2009
World journal of gastroenterology
Abstract: PreS deletions, C1653T, T1753V, and A1762T/G1764A are associated with an increased risk of HCC.
Associations between hepatitis B virus mutations and the risk of hepatocellular carcinoma: a meta-analysis.
PMID: 19574418
2009
Journal of the National Cancer Institute
Result: The most commonly reported HBV mutations associated with HCC risk were PreS mutations, A1762T/G1764A, G1896A, T1753V, C1653T, and C1858T.
Result: The risk estimates of HCC for PreS mutations, C1653T, T1753V, A1762T/G1764A, G1896A, and C1858T in individual case-control and cohort studies and summary estimates are shown in Figure 2.
Result: The statisticall
HBV A1762T, G1764A mutations are a valuable biomarker for identifying a subset of male HBsAg carriers at extremely high risk of hepatocellular carcinoma: a prospective study.
PMID: 18844615
2008
The American journal of gastroenterology
Introduction: The common precore mutation (G1896A), mutations in enhancer II (C1653T) and the basal core promoter (T1753V and the double mutations, A1762T, G1764A), and deletions in the pre-S region have been reported to be associated with the development of HCC.
Result: Mutations at nucleotide (nt) 1653 from C to T and nt 1753 from T to A, G or C (T to V) have been reported to be associated with severe chronic hepatitis B and the development of
ViMRT
HBV mutation literature information.
PMID: 
2011
The American journal of gastroenterology
