literature

Phosphatase and tensin homologue genetic polymorphisms and their interactions with viral mutations on the risk of hepatocellular carcinoma.

PMID: 25881591 2015 Chinese medical journal

Introduction: We and others have reported that HBV mutations C1653T, T1753V, A1762T/G1764A, T1674C/G, and C1766T/T1768A in the enhancer II/basal core promoter (EnhII/BCP) region; G1899A, C2002T, A2159G, A2189C, and G2203A/T in the precore/core region; as well as T53C,

PMID: 25737728 2014 Hepatitis monthly

Abstract: Additionally, several mutations were found in the BCP region with the following incidence rate; C1653 T (8.6%), A1752 G (10.8%),1762 AGG--TGA 1764 (26.9%), C1766T(2.2%),T1768 A (10.8%), C1858 T (64.5%), G1896 A (25.8%).

Result: Among the basal core promoter mutations, A1762T-G1764A double mutation was present in 26.9%, C1653T in 8.6%, A1752G in 10.8% and C1766T in 2.2% of the isolates.

Novel point and combo-mutations in the genome of hepatitis B virus-genotype D: characterization and impact on liver disease progression to hepatocellular carcinoma.

PMID: 25333524 2014 PloS one

Result: Mutation C1653T in enhancer-II and T1753C in BCP, which were reported previously as risk factor for HCC in HBV-genotype C, were not observed with significantly enhancing frequencies from nLF to HCC through LF and LC in HBV-genotype D infection (p = 0.079, 0.14 respectively).

Table: C1653T

Discussion: According to the previous studies in HBV genotype B, genotype C and few studies with genotype D, BCP_A1762T/G1764A, precore_G1896A,

PMID: 25283864 2014 Acta virologica

Abstract: In HBV-GN patients, missense nucleotide mutations of C1653T, A1726C, A1727T, C1730G, T1753C, A1762T, and G1764A were detected in 84% of subjects, all located in the trans-acting regulatory region of the X gene.

Mother-to-child transmission of hepatitis B virus: evolution of hepatocellular carcinoma-related viral mutations in the post-immunization era.

PMID: 24973814 2014 Journal of clinical virology

Abstract: T1753V, C1653T, and G1899A were infrequent in the mother-child pairs.

Novel natural mutations in the hepatitis B virus reverse transcriptase domain associated with hepatocellular carcinoma.

PMID: 24788140 2014 PloS one

Introduction: A recent meta-analysis including a total of 11,582 HBV-infected participants revealed that deletions in the pre-S gene and mutations of C1653T, T1753V and A1762T/G1764A in the basal core promoter (BCP)/enhancer II (EnhII) region had statistically significant summary odds ratios (OR) for HCC.

Introduction: Over the past few years, we defined that a high prevalence of the HBV C1 genotype, pre-S deletion and pre-S2 start codon mutation, C1653

The Effect of HBV Genotype C on the Development of HCC Differs Between Wild-Type Viruses and Those With BCP Double Mutations (T(1762)A(1764)).

PMID: 24693312 2014 Hepatitis monthly

Introduction: Some mutations in HBV genome such as G1896A, C1653T, T1753V, the BCP double mutations (T1762A1764), and pre-S region deletions have been reported to be associated with HCC development.

Combinations of eight key mutations in the X/preC region and genomic activity of hepatitis B virus are associated with hepatocellular carcinoma.

PMID: 24344773 2014 Journal of viral hepatitis

Abstract: Accumulation of eight key mutations located in the X/preC regions of the hepatitis B virus (HBV) genome (G1613A, C1653T, T1753V, A1762T, G1764A, A1846T, G1896A and G1899A) is a risk marker for the development of hepatocellular carcinoma (HCC).

Abstract: In patients with >=6 mutations, the combination of [G1613A + C1653T + A1846T + G1896A] mutations was closely l

Synergistic effects of A1896, T1653 and T1762/A1764 mutations in genotype c2 hepatitis B virus on development of hepatocellular carcinoma.

PMID: 23383661 2013 Journal of viral hepatitis

Discussion: In the HBx region, the presence of the C1653T mutation was significantly associated with the development of HCC in earlier studies.

Discussion: In view of this synergistic effect, our study results showed that the combined BCP A1762T/G1764A and C1653T mutations occurred more frequently in the HCC than in the CHB group and suggest that the C1653T in addition to the BCP double mutation may be a promoter of HCC development in patients with

PMID: 23104706 2013 Annals of surgical oncology

Abstract: RESULTS: The genomic changes such as the G1896A at precore, the A1762T/G1764A at BCP, the C1653T and the T1753V at X gene, and pre-S2 deletion were not significantly associated with postoperative recurrence of HCC or survival of patients after curative resection.

Introduction: The X gene mutations (two of the most common being C1653T and T1753V) and pre-S2 gene deletions have been associated with increased incidence of

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