literature

HBV mutation literature information.

Qidong hepatitis B virus infection cohort: a 25-year prospective study in high risk area of primary liver cancer.

PMID: 29479565 2018 Hepatoma research

Introduction: By using capillary gel electrophoresis, we found that it was the short fragment, rather than larger fragment, contributing to the association of Pre-S deletion with HCC., In addition to the above novel findings, we also verified the association of some known HBV mutations, such as HBV pre-S2 start codon mutation, C1653T and T1753C, with HCC in Qidong.

Introduction: While A1762T/G1764A, C1653T, A799G, A987G, T1055A, pre-S deletion could be detected in the plasma long

The mutation of hepatitis B virus and the prognosis of hepatocellular carcinoma after surgery: a pilot study.

PMID: 29628773 2018 Cancer management and research

Introduction: The X gene mutations (two of the most common being C1653T and T1753V) and Pre S2 gene deletions have been associated with increased incidence of HCC.

Molecular characterization of hepatitis B virus in Vietnam.

PMID: 28859616 2017 BMC infectious diseases

Method: Mutations in the BCP (C1653T, T1674C/G, T1753 V, A1762T, G1764/A, C1766T, and T1768A) and the PC/core region (G1899A, C2002T, A2159G, A2189C, and G2203A/T) associated with HCC were also analyzed.

Table: C1653T

Complete genome sequencing and clinical analysis of intrahepatic hepatitis B virus cccDNA from HCC.

PMID: 28478205 2017 Microbial pathogenesis

Abstract: Finally, significantly higher levels of preoperative alpha-fetoprotein were observed in patients harboring the G1078T, C1653T, G1727A, C1913A, T1978C, or C3116T mutations at the cccDNA level.

Abstract: RESULTS: High frequencies of C1653T, T1753V, and A1762T/G1764A cccDNA mutations were observed in both tumor and non-tumor tissues.

Clustering infection of hepatitis B virus genotype B4 among residents in Vietnam, and its genomic characters both intra- and extra-family.

PMID: 28753615 2017 PloS one

Result: There were no C1653T mutations, two (4.5%) T1753V mutations, five (11.4%) double mutations of A1762T/G1764A, and three (6.8%) double mutations of C1766T/T1768A.

Discussion: But looking at the promoter region mutations, G1613A mutation was identified in 10.3% of these 31 strains, C1653T was 0%, T1753V was 3.2%, A1762T/G1764A was 16.1%, and C1766T /T1768A was 3.2%.

Discussion: Reported promoter mutations are G1613A, C1653T, and

Contribution of C1485T mutation in the HBx gene to human and murine hepatocarcinogenesis.

PMID: 28874700 2017 Scientific reports

Result: Among these five HBx mutations, C1485T and C1653T mutations were more frequently detected in HCC than in non-HCC cases (Table 1).

Result: Collectively, these results suggest that C1485T and C1653T mutations in HBx contribute more significantly to HBV-related hepatocarcinogenesis in patients without LC than in those with LC where direct role of HBx should be less critical.

Result: Following the identification of the susceptible viral mutations (the C1485T

PMID: 27340355 2016 World journal of gastroenterology

Abstract: Out of 240 CHB patients, 25 (10%) had C1653T and 33 (14%) had T1753V mutation in X region; 157 (65%) had A1762T/G1764A mutations in BCP region, 50 (21%) had G1896A mutation in precore region and 67 (28%) had pre-S deletions.

HBx mutations promote hepatoma cell migration through the Wnt/beta-catenin signaling pathway.

PMID: 27420729 2016 Cancer science

Introduction: A1762T/G1764A (TA) mutations in the core promoter, which overlap with the HBx gene, are found commonly in HCC and are independent risk factors for the progression of HCC during chronic HBV infection.12 In vivo studies suggest that the TA mutant increases the replication capacity of HBV and suppresses HBeAg serum levels.13 A1762T/G1764A mutations are also predictors of postoperative survival in patients with HBV-related HCC.14 A1762T/T1764A<

Hepatitis B virus mutations, expression quantitative trait loci for PTPN12, and their interactions in hepatocellular carcinoma.

PMID: 27075395 2016 Cancer medicine

Result: Of those 19 hotspot mutations, C1653T, T1674C/G, A1703G, G1719T, T1727A/G, T1753C, A1762T, G1764A, G1799C, G1899A, G1915A/C, and C1969T were significantly associated with an increased risk of HCC, whereas C1673T, A1726C, C1730G, and A1752G were significantly associated with a reduced risk of

PMID: 26577140 2016 Clinical microbiology and infection

Abstract: Among all the patients with genotype C viruses, the patients with LC had higher prevalence of C1653T, A1762T/G1764A and G1896A mutation frequency, higher hepatitis B e antigen (HBeAg) -negative rates, lower viral load, lower elevated alanine aminotransferase and lower anti-HBe positive rates than CHB patients.

Abstract: Patients with HBV genotype C viruses, high viral load and C1653T, A1762T/G1764A, G1896A mutant viruses, were more susceptible to developing

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