literature

HBV mutation literature information.

Qidong hepatitis B virus infection cohort: a 25-year prospective study in high risk area of primary liver cancer.

PMID: 29479565 2018 Hepatoma research

Introduction: By using capillary gel electrophoresis, we found that it was the short fragment, rather than larger fragment, contributing to the association of Pre-S deletion with HCC., In addition to the above novel findings, we also verified the association of some known HBV mutations, such as HBV pre-S2 start codon mutation, C1653T and T1753C, with HCC in Qidong.

Introduction: While A1762T/G1764A, C1653T, A799G, A987G, T1055A, pre-S deletion could be detected in the plasma long

The mutation of hepatitis B virus and the prognosis of hepatocellular carcinoma after surgery: a pilot study.

PMID: 29628773 2018 Cancer management and research

Introduction: The X gene mutations (two of the most common being C1653T and T1753V) and Pre S2 gene deletions have been associated with increased incidence of HCC.

Molecular characterization of hepatitis B virus in Vietnam.

PMID: 28859616 2017 BMC infectious diseases

Method: Mutations in the BCP (C1653T, T1674C/G, T1753 V, A1762T, G1764/A, C1766T, and T1768A) and the PC/core region (G1899A, C2002T, A2159G, A2189C, and G2203A/T) associated with HCC were also analyzed.

Table: C1653T

Clustering infection of hepatitis B virus genotype B4 among residents in Vietnam, and its genomic characters both intra- and extra-family.

PMID: 28753615 2017 PloS one

Result: There were no C1653T mutations, two (4.5%) T1753V mutations, five (11.4%) double mutations of A1762T/G1764A, and three (6.8%) double mutations of C1766T/T1768A.

Discussion: But looking at the promoter region mutations, G1613A mutation was identified in 10.3% of these 31 strains, C1653T was 0%, T1753V was 3.2%, A1762T/G1764A was 16.1%, and C1766T /T1768A was 3.2%.

Discussion: Reported promoter mutations are G1613A, C1653T, and

Complete genome sequencing and clinical analysis of intrahepatic hepatitis B virus cccDNA from HCC.

PMID: 28478205 2017 Microbial pathogenesis

Abstract: Finally, significantly higher levels of preoperative alpha-fetoprotein were observed in patients harboring the G1078T, C1653T, G1727A, C1913A, T1978C, or C3116T mutations at the cccDNA level.

Abstract: RESULTS: High frequencies of C1653T, T1753V, and A1762T/G1764A cccDNA mutations were observed in both tumor and non-tumor tissues.

Contribution of C1485T mutation in the HBx gene to human and murine hepatocarcinogenesis.

PMID: 28874700 2017 Scientific reports

Result: Among these five HBx mutations, C1485T and C1653T mutations were more frequently detected in HCC than in non-HCC cases (Table 1).

Result: Collectively, these results suggest that C1485T and C1653T mutations in HBx contribute more significantly to HBV-related hepatocarcinogenesis in patients without LC than in those with LC where direct role of HBx should be less critical.

Result: Following the identification of the susceptible viral mutations (the C1485T

PMID: 26577140 2016 Clinical microbiology and infection

Abstract: Among all the patients with genotype C viruses, the patients with LC had higher prevalence of C1653T, A1762T/G1764A and G1896A mutation frequency, higher hepatitis B e antigen (HBeAg) -negative rates, lower viral load, lower elevated alanine aminotransferase and lower anti-HBe positive rates than CHB patients.

Abstract: Patients with HBV genotype C viruses, high viral load and C1653T, A1762T/G1764A, G1896A mutant viruses, were more susceptible to developing

PMID: 27727182 2016 International journal of molecular sciences

Abstract: A total of 10 mutations (including pre-S2 start codon mutation and pre-S deletion in pre-S gene, G1613A, C1653T, A1762T, and G1764A mutations in X gene, A2159G, A2189Y, G2203W, and C2288R mutations in C gene) showed an increased risk of HCC.

Abstract: In the validation study, pre-S deletion, C1653T, A1762T/G1764A

Hepatitis B virus mutations, expression quantitative trait loci for PTPN12, and their interactions in hepatocellular carcinoma.

PMID: 27075395 2016 Cancer medicine

Result: Of those 19 hotspot mutations, C1653T, T1674C/G, A1703G, G1719T, T1727A/G, T1753C, A1762T, G1764A, G1799C, G1899A, G1915A/C, and C1969T were significantly associated with an increased risk of HCC, whereas C1673T, A1726C, C1730G, and A1752G were significantly associated with a reduced risk of

PMID: 27340355 2016 World journal of gastroenterology

Abstract: Out of 240 CHB patients, 25 (10%) had C1653T and 33 (14%) had T1753V mutation in X region; 157 (65%) had A1762T/G1764A mutations in BCP region, 50 (21%) had G1896A mutation in precore region and 67 (28%) had pre-S deletions.

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