In silico functional and structural characterization of hepatitis B virus PreS/S-gene in Iranian patients infected with chronic hepatitis B virus genotype D.
Introduction: Also, mutations may occur in association with either vaccine-induced immune-escape (P120T, K122R, T126S, Q129H, G130N, M133L, and M133T) or in relation to the patients with occult HBV infection (Y100C, C124R, C124Y, K141E, and D144A).
Molecular characterization of hepatitis B virus in blood donors in Botswana.
Result: Twelve mutations including diagnostic escape mutations (sY100C, sR122K, sT123A, sC124R, sM133T), vaccine escape mutations (sT126N, sQ129R, sM133L, sF134V) and immunoglobulin therapy failure (sG119R, sG130N, PMID: 27182775
2016
PloS one
Introduction: In this study, four mutations (sC124R, sC124Y, sK141E, and sD144A) strongly decreased the sensitivity of HBV detection in seven commercial HBsAg immunoassays.
Occult hepatitis B virus infection among blood donors in Colombia.
Discussion: Thirteen MHR mutations (G119R, P120T, C124R, C124Y, I126S, Q129R, S136P, C139R, T140I, K141E, D144A, G145A, and G145R) were detected and functionally characterized in vitro and in vivo.
Influence of mutations in hepatitis B virus surface protein on viral antigenicity and phenotype in occult HBV strains from blood donors.
Abstract: Four out of the 13 mutations (C124R, C124Y, K141E, and D144A) strongly decreased the analytical sensitivity of seven commercial HBsAg immunoassays, and 10 (G119R, C124Y, I126S, Q129R, S136P, C139R, T140I, K141E, D144A, and G145R) significantly impaired virion and/or S protein secretion in both HuH7 cells and mice.
Hepatitis B virus S gene mutants in a patient with chronic active hepatitis with circulating Anti-HBs antibodies.
HBV mutation literature information.
PMID: 
2020
Heliyon
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