literature

HBV mutation literature information.

Mutations in the HBV PreS/S gene related to hepatocellular carcinoma in Vietnamese chronic HBV-infected patients.

PMID: 35390033 2022 PloS one

Result: Among them, 4 point-mutations W4P/R/Y, S5L/T, A90T/S/G, and L108V/I were observed with the significantly higher rates in the HCC group compared to non-HCC group: W4P/R/Y (12.2% vs 2%, p = 0.005), S5L/T (6.1% vs 1%, p = 0.055), A90T/S/G (6.1% vs 0.5%, p = 0.026) and L108V/I (6.1% vs 0.5%, p = 0.026) (Table 2).

Table: A90T/S

Discussion: They were W4P/R/Y and S5L/T (p = 0.055) on the NTCP region;

rt269I Type of Hepatitis B Virus (HBV) Polymerase versus rt269L Is More Prone to Mutations within HBV Genome in Chronic Patients Infected with Genotype C2: Evidence from Analysis of Full HBV Genotype C2 Genome.

PMID: 33803998 2021 Microorganisms

Result: We found a total of five types of signature NS mutations in the S ORF (I84T/M/L/V and A90T/V in PreS1, F141L in PreS2, and I68T and L213I/S in S).

Table: A90T/V

[Analysis of hepatitis B virus (HBV) preS1, preS2 and S gene regions from patient groups infected with HBV genotype D].

PMID: 29642827 2018 Mikrobiyoloji bulteni

1Abstract: The amino acid variants were as follows; PreS1: A33T, A39T, P41K, D44del, D50N, T51P, D54N, L65P/M, F67L, W77T, A81S, Q82E, I84T, L85I/M, Q86H/T, L88S, A90T/V, N91K/del, A95P, S96A, T97I/A,

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