Precore/core mutations of hepatitis B virus genotype D arising in different states of infection.
PMID: 35415256
2022
Clinical and experimental hepatology
Discussion: They also found that F24Y, E64D, and V91S/T mutations were located in the T-cell epitope regions, and E77Q, A80I/T/V, and L116I were located within the B-cell epitope regions.
Discussion: reported 6 core mutations (F24Y, E64D, E77Q, A80I/T/V, L116I, and E180A) related to the progression of the disease to cirrhosis and HCC.
Conformational Plasticity of Hepatitis B Core Protein Spikes Promotes Peptide Binding Independent of the Secretion Phenotype.
Discussion: Both variants differ only in positions, T33N and A80I.
The Correlation Between Hepatitis B Virus Precore/Core Mutations and the Progression of Severe Liver Disease.
PMID: 30406036
2018
Frontiers in cellular and infection microbiology
Abstract: Two precore mutations, W28* and G29D, and six core mutations, F24Y, E64D, E77Q, A80I/T/V, L116I, and E180A were significantly associated with the development of cirrhosis and HCC.
Discussion: We identified four core protein mutations that were significantly associated with cirrhosis: F24Y, A80I/V, L116I, and
HBV mutation literature information.
PMID: 
2022
Clinical and experimental hepatology
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