literature

HBV mutation literature information.

A336C/A336T/T337C variations in HBV core gene and spontaneous hepatitis B e antigen loss in chronic hepatitis B patients.

PMID: 21569538 2011 Virology journal

Result: A336C/A336T/T337C variations occurred in 26/87 (29.9%) chronic hepatitis B patients with genotype B and 14/79 (17.7%) patients with genotype C, and Chi-square test showed that there was no significant difference in the rate of A336C/A336T/T337C variations between HBV genotype B and C (chi2 = 3.3, P = 0.07, See Table 2).

Discussion: Therefore, A336C/A336T/T337C variations were proposed to be another major mechanism to explain spontaneous HBeAg loss in the natural history of chronic HBV infection as well as

Clinical significance of a set of single nucleotide polymorphisms of hepatitis B virus core gene in Chinese Han patients with chronic hepatitis B.

PMID: 18814242 2008 Journal of medical virology

Abstract: 5 SNPs, A261T, A336C, A336T T337C and T385C, were found to be associated with RFLP patterns change and only SNP A336C or A336T caused the substitution of Glu-83 with Asp in HBcAg.

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