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 HBV mutation literature information.


  Hepatitis B virus core promoter mutations G1613A and C1653T are significantly associated with hepatocellular carcinoma in genotype C HBV-infected patients.
 PMID: 22014121       2011       BMC cancer
Discussion: A recent study from China revealed that 1613 and 1653 mutations were included in mutations frequently detected in HCC patients; however, core region mutants A2189C and G2203W were independent risk factors for HCC.


  Comparison study on the complete sequence of hepatitis B virus identifies new mutations in core gene associated with hepatocellular carcinoma.
 PMID: 20699378       2010       Cancer epidemiology, biomarkers & prevention
Abstract: In the validation study, A2159G, A2189C, and G2203W showed consistent associations with HCC by univariate analysis.
Abstract: Multivariate analysis showed that A2189C and G2203W were independent risk factors for HCC.
Abstract: RESULTS: The pre-S deletion and 12 point mutations, namely, the pre-S2 start codon mutation, T53C in the pre-S2 gene, T766A in the S gene, G1613A, C1653T,



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