Abstract: A series of novel PLC-related mutations including A2159G, A2189C and G2203W at the C gene, A799G, A987G and T1055A at the P gene of HBV genome were identified by using samples from the cohort.
Introduction: These mutations include A2159G, A2189C and G2203W at C gene, A799G, A987G and T1055A at P gene, and A1479T at X gene.
Molecular characterization of hepatitis B virus in Vietnam.
Method: Mutations in the BCP (C1653T, T1674C/G, T1753 V, A1762T, G1764/A, C1766T, and T1768A) and the PC/core region (G1899A, C2002T, A2159G, A2189C, and G2203A/T) associated with HCC were also analyzed.
Table: A2159G
Potential Susceptibility Mutations in C Gene for Hepatitis B-Related Hepatocellular Carcinoma Identified by a Two-Stage Study in Qidong, China.
PMID: 27727182
2016
International journal of molecular sciences
Discussion: Among the 10 HCC-related mutations acquired from the full genome analysis in stage 1, four (A2159G, A2189Y, G2203W, and C2288R mutations) were located in the C gene.
Discussion: Furthermore, in this full HBV genome comparison between 30 HCC cases and 30 controls, we also identify some rarely reported or new HCC-related mutations, including G1613A in the X gene, and A2159G, A2189Y, G2203W, and C2288R mutations in the <
New point mutations in surface and core genes of hepatitis B virus associated with acute on chronic liver failure identified by complete genomic sequencing.
Result: In ACLF patients with genotype B virus, the substitution rates of T216C, G285A, A1846T/G, G1896A, C1913A/G, A2159G/C, and A2189T/C were 70.6%, 60.3%, 66.2%, 76.5%, 63.2%, 47.1%, and 50.0%, respectively; while in ACLF patients with genotype C virus, the substitution rates were 8.3%, 13.9%, 44.4%, 63.9%, 41.7%, 41.7%, 47.2%, respectively.
Discussion: Although the symptoms of early ACLF are similar to the symptoms of CHB-S, the prognosis of PMID: 25881591
2015
Chinese medical journal
Introduction: We and others have reported that HBV mutations C1653T, T1753V, A1762T/G1764A, T1674C/G, and C1766T/T1768A in the enhancer II/basal core promoter (EnhII/BCP) region; G1899A, C2002T, A2159G, A2189C, and G2203A/T in the precore/core region; as well as T53C, PMID: 24788140
2014
PloS one
Introduction: In addition, A2159G and A2189C in the core gene and
Introduction: Over the past few years, we defined that a high prevalence of the HBV C1 genotype, pre-S deletion and pre-S2 start codon mutation, C1653T, T1753A/G, C1766T, and T1768A mutations in the BCP/EnhII region, and A2159G, A2189C, and G2203W in the core gene are associated with HCC in Qidong.
Hepatitis B virus genotype B and mutations in basal core promoter and pre-core/core genes associated with acute-on-chronic liver failure: a multicenter cross-sectional study in China.
Abstract: Comparing with CHB-S, the A1762T/G1764A mutation in genotype B and the A2159G mutation in genotype C were significantly more common in Abstract: The A1762T/G1764A, A1846T and G1896A mutations were significantly more common in HB-ACLF patients infected with either genotype B or C as compared with CHB-M, whereas the C1913A/G and A2159G mutations were more associated with HB-ACLF in genotype C patients.
Comparison study on the complete sequence of hepatitis B virus identifies new mutations in core gene associated with hepatocellular carcinoma.
PMID: 20699378
2010
Cancer epidemiology, biomarkers & prevention
Abstract: RESULTS: The pre-S deletion and 12 point mutations, namely, the pre-S2 start codon mutation, T53C in the pre-S2 gene, T766A in the S gene, G1613A, C1653T, A1762T, G1764A in the X gene, and G1899A, C2002T, A2159G, A2189C, and G2203W (A or T) in the pre-C/C gene, showed close associations with
HBV mutation literature information.
PMID: 
2018
Hepatoma research
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