literature

HBV mutation literature information.

Characterization and Clinical Significance of Natural Variability in Hepatitis B Virus Reverse Transcriptase in Treatment-Naive Chinese Patients by Sanger Sequencing and Next-Generation Sequencing.

PMID: 31189581 2019 Journal of clinical microbiology

Result: In addition, except for only 1 patient with a mutation at rt181 (A181T) in the ALD group, there was not any primary resistance muta

Discussion: In this study, except rtA181T, the classical primary drug resistance mutations (i.e., I169T, A181T/V, T184A/C/F/G/I/L/M/S, A194T, S202C/G/I, M204I/V/S, N236T, and M250I/L/V) were not detected by Sanger sequencing in treatment-naive patients (Table 3), which was consistent with previous reports.

Frequency of Hepatitis B Virus Resistance Mutations in Women Using Tenofovir Gel as Pre-Exposure Prophylaxis.

PMID: 31248149 2019 Viruses

Abstract: None of the known tenofovir resistance mutations (M240V/I, L180M, A194T, V214A, N238T) were identified in any individuals.

Result: No mutations known to cause tenofovir resistance (L180M, A181I/V, A194T, M204V/I, V214A, Q215S, N236T) or lamuvudine (3TC) resistance (L80V/I, I169T, V173L, L180M, A181T, T184S,

Method: Mutation of rtI169T (0.12%), rtT184G (0.06%), rtA194T (0.07%), and rtM250V/L (0.20%) had a very low pooled incidence (Figure 1).

Table: A194T

Hepatitis B infection among HIV infected individuals in Gabon: Occult hepatitis B enhances HBV DNA prevalence.

PMID: 29315352 2018 PloS one

Method: As previously described, we used the Mutation Reporter Tool (MRT) software (http://hvdr.bioinf.wits.ac.za/mrt/) to look for HBV resistance-associated mutations (RAMs) in the Polymerase catalytic domain represented by major RAMs (A181T/V/S, A194T, M204V/I/S and N236T) and compensatory RAMs (I169T, V173L, L180M, S202G/I and M250V.

A systematic review of hepatitis B virus (HBV) drug and vaccine escape mutations in Africa: A call for urgent action.

PMID: 30080852 2018 PLoS neglected tropical diseases

Introduction: HBV resistance to TDF is not well characterised, but there are emerging data from in vitro studies associating Pol mutations rtA194T and rtN236T with decreased susceptibility.

Result: Although TDF has a high genetic barrier to resistance, and is associated with reliable suppression of HBV viraemia, mutations rtN236T and rtA194T, which have been linked with resistance to both TDF and ADV, have been identified in Southern Africa in both treatment naive and treatment experienced patients.

Result: The rtM204I/V mutation by itself confers resistance to 3TC; in combination with

Genotyping of HBV and tracking of resistance mutations in treatment-naive patients with chronic hepatitis B.

PMID: 28740410 2017 Infection and drug resistance

Abstract: The mutations were rtA194T, rtL180M + rtM204V, rtS202I, rtM204I, and rtA181S.

Discussion: In the literature, there are no mutations in the S region associated with the rtA194T resistance mutation, confirming the results found.

Discussion: One of the resistance mutations found in the Northeastern Region was rtA194T, which can be associated with resistance to TDF, which has shown

Mutations associated with drug resistance and prevalence of vaccine escape mutations in patients with chronic hepatitis B infection.

PMID: 28500726 2017 Journal of medical virology

Abstract: Six patients (7%) exhibited resistance mutations to LAM, ETV, and TDF: two with patterns L180M + M204V and four with other different patterns: L80I + L180M + M204I; L80V + L180M + M204V; M204I; A194T.

HBV Drug Resistance Substitutions Existed before the Clinical Approval of Nucleos(t)ide Analogues: A Bioinformatic Analysis by GenBank Data Mining.

PMID: 28749433 2017 Viruses

Introduction: According to several clinical practice guidelines and authoritative reviews, NUCr substitutions can be classified into two categories: primary NUCr substitutions at 8 codons (rtI169T, rtA181T/V, rtT184A/C/F/G/I/L/M/S, rtA194T, rtS202C/G/I, rtM204I/V, rtN236T and rtM250I/L/V) and secondary substitutions at 3 codons in RT<

Dynamics of Genotypic Mutations of the Hepatitis B Virus Associated With Long-Term Entecavir Treatment Determined With Ultradeep Pyrosequencing: A Retrospective Observational Study.

PMID: 26825915 2016 Medicine

Result: Other substitutions (rtI169T/V, rtT184A/I, rtA194 V/T, rtV214A, rtM250 V) were present at low levels (<1%).

Result: Other substitutions (rtI169T/V, rtV173A/M, rtT184A/I, rtA194 V/T, rtQ215R/H, rt

Molecular characterization of hepatitis B virus from chronically-infected patients in Niamey, Niger.

PMID: 26899956 2016 International journal of infectious diseases

Abstract: Amino acid substitutions found in HBV sequences obtained here included P120T, S143L, G145A and A194T.

Abstract: These substitutions were characterized as being associated with modified antigenicity and, notably, with impaired serological detection of HBsAg, while the A194T variant was found to have a controversial role in reduced susceptibility to tenofovir.

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