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 HBV mutation literature information.


  Lower mutation frequency of BCP/precore regions in e antigen-negative chronic HBV-infected children instead of adults patients.
 PMID: 25822176       2015       PloS one
Result: Notably, the frequency of the G1896A mutation in the HBeAg-negative child patients was significantly lower than in the HBeAg-negative adult patients (41.1% vs 91.7%, P < 0.001), and similar results were also observed for other BCP/precore mutations such as A1846T (17.8% vs 37.5%, P = 0.010) and the G1899A substitution (7.8% vs 20.8%, P = 0.026).
Result: Notably, the higher mutation ratio in the adult patients than in the child patients for these combined mutations (G1896A/A1846T: 35.4%vs12.2%, P<0.001; G1896A/G1899A: 18.8%vs4.6%, P = 0.015; G1896A/


  Clinical utility of complex mutations in the core promoter and proximal precore regions of the hepatitis B virus genome.
 PMID: 25625002       2015       World journal of hepatology
Abstract: We previously demonstrated that the accumulation of >= 6 mutations at eight key nucleotides located in these regions (G1613A, C1653T, T1753V, A1762T, G1764A, A1846T, G1896A, and G1899A) is a useful marker to predict the development of HCC regardless of advanced liver disease.


  Combinations of eight key mutations in the X/preC region and genomic activity of hepatitis B virus are associated with hepatocellular carcinoma.
 PMID: 24344773       2014       Journal of viral hepatitis
Abstract: Accumulation of eight key mutations located in the X/preC regions of the hepatitis B virus (HBV) genome (G1613A, C1653T, T1753V, A1762T, G1764A, A1846T, G1896A and G1899A) is a risk marker for the development of hepatocellular carcinoma (HCC).
Abstract: In patients with >=6 mutations, the combination of [G1613A + C1653T + A1846T + G1896A] mutations was closely l


  Hepatitis B virus genotype B and mutations in basal core promoter and pre-core/core genes associated with acute-on-chronic liver failure: a multicenter cross-sectional study in China.
 PMID: 26202756       2014       Hepatology international
Abstract: A multivariate analysis showed that factors such as HBV genotype B, age >=40 years and A1762T/G1764A, A1846T and G1896A mutations were independently associated with the development of HB-ACLF.
Abstract: CONCLUSION: Chronic HBV infection with genotype B, A1762T/G1764A, A1846T and G1896A mutations has a higher possibility to develop HB-ACLF.
Abstract: The A1762T/G1764A, A1846T and G1896A mutations were significantly m


  Clinical and virological implications of A1846T and C1913A/G mutations of hepatitis B virus genome in severe liver diseases.
 PMID: 24282424       2013       Hepatitis monthly
Abstract: CONCLUSIONS: Our findings suggest that CHB or LC patients infected with HBV A1846T and C1913A/G mutants are more susceptible to develop ACLF.
Abstract: Multivariable analysis indicated that A1846T and C1913A/G mutations were independent factors for ACLF (OR = 2.86 and 5.93, respectively), suggesting an association between the mutations and development of ACLF.
Abstract: RESULTS: Our results revealed significantly higher incidences (P < 0.05) of genotype B with C1913A/G or  PMID: 24006435       2013       Journal of virology
Abstract: HLA-DP polymorphisms promoting HBV clearance were associated with a lower prevalence of mutations increasing HCC risk (C1653T, T1674C/G, A1846T, G1896A and pre-S2 mutations and pre-S deletion in genotype C) and a higher prevalence of mutations decreasing HCC risk (G1652A, T1673C, T1674C, G1719T, G1730C, and G1799C in genotype B and A1727T in genotype C).


  Hepatitis B virus subgenotype C2- and B2-associated mutation patterns may be responsible for liver cirrhosis and hepatocellular carcinoma, respectively.
 PMID: 23903686       2013       Brazilian journal of medical and biological research
Abstract: Four patterns (C1810T, A1846T, G1862T, and G1896A) were significantly associated with HCC compared with LC.
Abstract: Multivariate regression analyses showed that HBV subgenotype C2 and C2-associated mutation patterns (C1653T, T1753C, A1762T, and G1764A) were independent risk factors for LC when CHB was the control, and that B2-associated mutation patterns (C1810T, A1846T, G1862T,


  [Analysis of the relationship between hepatitis B virus precore and basal core promoter mutations and acute-on-chronic liver failure].
 PMID: 23207226       2012       Zhonghua gan zang bing za zhi
Abstract: Mutations G1899A, T1753V, and A1846T were correlated with disease recovery.
Abstract: Significant decreases in the MELD score were accompanied by decreases in the A1846T mutation.
Abstract: The G1899A, T1753C, and A1846T mutations were associated with HB-ACLF response to treatment and improvement in liver function.


  Mutational complex genotype of the hepatitis B virus X /precore regions as a novel predictive marker for hepatocellular carcinoma.
 PMID: 22136288       2012       Cancer science
Abstract: Eight high-frequency mutations (G1613A, C1653T, T1753V, A1762T, G1764A, A1846T, G1896A and G1899A) were significantly associated with HCC.
Abstract: Whereas C1653T, T1753V, G1764A and A1846T were independent mutational factors for HCC, the significance of these individual mutations was negligible when analyzed with all clinico-virological variables.


  Precore/core promoter mutations and hepatitis B virus genotype in hepatitis B and C dually infected patients treated with interferon-based therapy.
 PMID: 22061616       2012       Antiviral research
Abstract: Age (HR=1.068, P=0.020), G1896A mutation (HR=0.140, P=0.01) and A1846T mutation (HR=0.086, P=0.018) were associated with HBsAg seroclearance independently.
Abstract: Based on Cox proportional hazards model, young age (hazard ratio (HR)=0.952, P=0.001), sustained virological response to HCV (HR=4.638, P=0.044), C1766T mutation (HR=5.216, P=0.003) and A1846T mutation (HR=2.332, P=0.031) correlated with HBV DNA reactivation (>=2000IU/ml) after therapy.



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