Abstract: The clonal frequencies of A1762T, G1764A, G1896A and A1846T were lower in patients with C/D than C2.
The mutation of hepatitis B virus and the prognosis of hepatocellular carcinoma after surgery: a pilot study.
PMID: 29628773
2018
Cancer management and research
Method: According to the sequencing outcome, HBV genotype and mutations (including A1752T/G, T1753C, G1757A, A1762T/G1764A, C1766T, T1768A, A1775G, C1799G, A1846T, T1858C, G1896A, G1898A, G1899A, and Pre S deletion) were confirmed by the BLAST analysis (http://blast.ncbi.nlm.nih.gov/Blast.cgi).
Result: According to different mutation regions, A1752T/G, T1753C,
Clinical and virological implications of A1846T and C1913A/G mutations of hepatitis B virus genome in severe liver diseases.
PMID: 29322851
2018
Scandinavian journal of gastroenterology
Abstract: A1846T mutation is significantly associated with poor prognosis of ACLF.
Abstract: A1846T was significantly associated with the mortality of ACLF patients within six months after the disease onset (OR 1.704, p = .041).
Abstract: CONCLUSION: Occurrence of A1846T and C1913A is positively associated with clinical presentations of severe liver disease.
Abstract: In vitro experiment revealed that A1846T mutant resulted in 3.20-fold and 1.85-fold increase of replication capacity and promoter activity, respectively compared with wild type counterpart (p < .001), while C1913A led to a s
Differential regulation of hepatitis B virus core protein expression and genome replication by a small upstream open reading frame and naturally occurring mutations in the precore region.
Discussion: A1846T has been associated with acute-on-chronic liver failure and HCC development, and can coexist with G1896A mutation (; our unpublished observation).
Discussion: At the immune clearance phase genotypes B and C could develop the A1846T mutation, which according to this study will increase core protein expression and genome replication (Table 1).
Association between hepatitis B virus basal core promoter/precore region mutations and the risk of hepatitis B-related acute-on-chronic liver failure in the Chinese population: an updated meta-analysis.
Abstract: CONCLUSIONS: HBV T1753V, A1762T/G1764A, A1846T, G1896A, and G1899A mutations are correlated with an increase in the risk of HB-ACLF.
Abstract: Statistically significant summary ORs for HB-ACLF were obtained for T1753V (1.99; 95 % confidence interval 1.30-3.02) and A1762T/G1764A (2.11; 95 %, 1.75-2.54) in the BCP region and for A1846T (3.33; 95 %, 2.23-4.97), G1896A (2.78; 95 %, 2.07-3.74), and G
Associations between hepatitis B virus basal core promoter/pre-core region mutations and the risk of acute-on-chronic liver failure: a meta-analysis.
Abstract: CONCLUSIONS: The HBV basal core promoter/pre-core mutations T1753V, A1762T, G1764A, C1766T, T1768A, A1846T, G1896A and G1899A, and an HBeAg-negative status correlate with an increased risk of HBV-ACLF.
Abstract: Several mutations were significantly correlated with ACLF: T1753V (1.889, 95 % confidence interval (CI) [1.357-2.631]), A1762T (2.696 [2.265-3.207]), PMID: 25625002
2015
World journal of hepatology
Abstract: We previously demonstrated that the accumulation of >= 6 mutations at eight key nucleotides located in these regions (G1613A, C1653T, T1753V, A1762T, G1764A, A1846T, G1896A, and G1899A) is a useful marker to predict the development of HCC regardless of advanced liver disease.
New point mutations in surface and core genes of hepatitis B virus associated with acute on chronic liver failure identified by complete genomic sequencing.
Abstract: The results of Illumina sequencing showed that the mutations at 7 sites (T216C, G285A, A1846T, G1896A, C1913A/G, A2159G, and A2189C) of 12 ACLF patients were significantly higher than those of 12 controls.
Result: As compared with non-ACLF cases, T216C, G285A, A1846T/G, G1896A, C1913A/G, A2159G/C, A2189T/C in genotype B and G285A, PMID: 25822176
2015
PloS one
Result: Notably, the frequency of the G1896A mutation in the HBeAg-negative child patients was significantly lower than in the HBeAg-negative adult patients (41.1% vs 91.7%, P < 0.001), and similar results were also observed for other BCP/precore mutations such as A1846T (17.8% vs 37.5%, P = 0.010) and the G1899A substitution (7.8% vs 20.8%, P = 0.026).
Result: Notably, the higher mutation ratio in the adult patients than in the child patients for these combined mutations (G1896A/A1846T: 35.4%vs12.2%, P<0.001; G1896A/G1899A: 18.8%vs4.6%, P = 0.015; G1896A/
HBV mutation literature information.
PMID: 
2021
BMC infectious diseases
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