Introduction: According to several clinical practice guidelines and authoritative reviews, NUCr substitutions can be classified into two categories: primary NUCr substitutions at 8 codons (rtI169T, rtA181T/V, rtT184A/C/F/G/I/L/M/S,
Discussion: This suggests that these atypical substitutions might not play important roles in the emergence of NUCr as compared to rtA181T/V, rtS202C/G/I, rtM204I/V and rtM250I/L/V.
De novo entecavir+adefovir dipivoxil+lamivudine triple-resistance mutations resulting from sequential therapy with adefovir dipivoxil, and lamivudine.
PMID: 27079793
2016
Annals of clinical microbiology and antimicrobials
Result: Additionally, 1 clone and 15 clones harboring rtA181 T mutations in in patients 3 and 4, respectively, showed sW172* mutations.
Result: In addition, 17.39 % (4/23) and 13.04 % (3/23) of the clones harbored the rtM204 I and rtA181 T mutations, respectively, which were not found by direct sequencing.
Result: In addition, one clone (5.0 %) bore rtM204 V+rtA181 T mutations.
Result: In patient 1, 3 clones harboring the rtA181 T mutation had s
Combined Analysis of the Prevalence of Drug-Resistant Hepatitis B Virus in Antiviral Therapy-Experienced Patients in Europe (CAPRE).
PMID: 26136470
2016
The Journal of infectious diseases
Abstract: The most frequently encountered primary mutation was M204V/I (48.7%), followed by A181T/V (3.8%) and N236T (2.6%).
[Drug-resistant mutations in hepatitis B virus found in chronic HBV carriers using PCR sequencing technology].
Abstract: Each of the NAs had dominant drug-resistant mutational profiles, with rtM204I+rtL180M+-rtL80I (30.9%) for LAM, rtA181T/N (21.3%), rtS213T/N (21.3%) and rtV214A (21.3%) for ADV, rtl180M (48%) for ETV, rtM204I for LdT, and rtA194T for tenofovir disoproxil fumarate (TDF).
Evolution of entecavir-resistant hepatitis B virus during entecavir and adefovir dipivoxil combination therapy.
PMID: 26889227
2016
Experimental and therapeutic medicine
Discussion: Furthermore, with prolonged treatment, whether the ADV-resistant variant (rtA181V/T or rtN236T) will be selected and linked with the ETV-resistant strain warrants additional investigation.
Possible Involvement of Multidrug-Resistant Hepatitis B Virus sW172* Truncation Variant in the ER Stress Signaling Pathway during Hepatocarcinogenesis.
PMID: 26567840
2016
Japanese journal of infectious diseases
Abstract: HBsAg levels were significantly higher in both supernatant of cells transfected with HBV wt and serum of mice injected with HBV wt, compared with that of HBV rtA181T/sW172* mutant.
Abstract: Full-length HBV wild type (wt) and HBV rtA181T/sW172* expression plasmids were transfected into HepG2 cell lines or were injected into C57BL/6 mice.
Abstract: Furthermore, GRP78 mRNA expression was increased 72 h post-transfection in HBV rtA181T/sW172* cells relative to HBV wt cells (P = 0.0154).
Abstract: HBV
Tenofovir monotherapy versus tenofovir and entecavir combination therapy in adefovir-resistant chronic hepatitis B patients with multiple drug failure: results of a randomised trial.
Abstract: However, lamivudine plus adefovir-resistant clones (rtA181T/N236T) acquired tolerance to TDF, and the rtN236T mutation was considered to be a causal substitution for TDF resistance.
Antiviral efficacy of entecavir versus entecavir plus adefovir for hepatitis B virus rtA181V/T mutants alone.
PMID: 26831605
2016
Saudi journal of gastroenterology
Abstrac
Abstract: BACKGROUND/AIMS: Hepatitis B virus (HBV) rtA181V/T mutants developed by long-term nucleos(t) ide analogue therapy are known to present cross-resistance for other nucleos (t) ide analogues, except entecavir (ETV).
Conclusion: In conclusion, findings of this study demonstrated that ETV monotherapy and ETV plus ADV therapy were clinically effective and comparable as rescue therapy for HBV rtA181V/T mutants alone.
Conclusion: Large-scale, long-term studies of rescue therapy for HBV rtA181V/T mutants alone should be conducted, and therapeutic plans for achievement of further antiviral efficacy for HBV rtA181V/T mutants alone should be established and recommended.
Dynamics of Genotypic Mutations of the Hepatitis B Virus Associated With Long-Term Entecavir Treatment Determined With Ultradeep Pyrosequencing: A Retrospective Observational Study.
Discussion: One study reported that the most commonly detected mutations were M204 V/I, M250 V/I, A181T/V, and N236T.
Discussion: UDPS indicated that NAr mutations were pre-existent at low percentages (ranging from 0.1% to 6.7%) at baseline, including rtV173A/M, rtL180 M, rtA181 V/T, rtS202G, rtM204I/V, rtV214A, rtQ215R/H
HBV mutation literature information.
PMID: 
2017
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