Discussion: rtN236T a primary mutation in the D domain, rtA181T/V at the B domain and rtQ215S at the C-D inter-domain have been associated with Adefovir and Lamivudine resistance were also observed in 8 cases.
The impact of the hepatitis B virus polymerase rtA181T mutation on replication and drug resistance is potentially affected by overlapping changes in surface gene.
Abstract: A series of mutant clones containing rtA181T and/or rtI233V mutations were constructed and determined the effect of these mutations on the replication ability and drug resistance.
Abstract: Among drug-resistant mutations, the single rtA181T mutation is known to confer cross-resistance to antiviral drugs.
Abstract: An in vitro study revealed that the effect of the rtA181T mutation on viral replication and drug resistance is dependent on the mutations in the overlapping surface gene.
Abstract: Compared to the rtA181T surface missense mutation
Novel natural mutations in the hepatitis B virus reverse transcriptase domain associated with hepatocellular carcinoma.
Result: It is worth noting that we did not observe any of the common NA-related resistance mutations including rtM204V/I, rtS202C/G/I, rtL180M, rtA181T/V, rtT184A/I/L/G/C/M, rtA194T, rtI169T, rtV173L, rtL80I, rtN236T, and PMID: 25493022
2014
World journal of gastroenterology
Abstract: Patients with the rtA181T mutant were primarily infected with genotype C and e-antigen negative HBV, while patients with the rtN236T mutant were primarily infected by genotype B HBV (chi(2) = 6.004, 7.159; P = 0.023, 0.007).
Abstract: The most prevalent mutations were rtA181T, rtV214A, and rtN236T.
Spontaneous HBsAg loss in Korean patients: relevance of viral genotypes, S gene mutations, and covalently closed circular DNA copy numbers.
PMID: 25320728
2014
Clinical and molecular hepatology
Discussion: In this regard, we previously found several point mutations in the MHR region and W172stop corresponding to the multidrug-resistant rtA181T mutation in polymerase impair the secretion of both virions and HBsAg.
Different mechanism of selection of adefovir-resistant mutant viruses during adefovir monotherapy in patients with lamivudine-resistant chronic hepatitis B.
Abstract: CONCLUSION: The high rate of ADV resistance in patients with LMV-resistance might be attributable to preexisting rtA181V/T mutant virus.
Abstract: During ADV therapy, most rtM204V/I mutants were replaced by wild type in all 3 patients without the rtA181V/T mutation and in one patient with the rtA181V/T mutation.
Abstract: In patients with the rtA181V/T mutation (n = 6), the rtA181V/T mutant overtook the rtM204V/I mutant in 3 of 4 patients wi
Virologic breakthrough in a patient with chronic hepatitis B by combination treatment with tenofovir disoproxil fumarate and entecavir.
PMID: 25061278
2014
Drug design, development and therapy
Conclusion: Further, there were no substitutions that could be associated with reduced TDF susceptibility (rtA181V/T, rtN236T, or rtA194T) in April 2013.
Discussion: For these 45 patients, which included ten with virologic breakthrough, both line probe assay and direct sequencing revealed no new amino acid substitutions, including substitutions that could be associated with reduced TDF susceptibility (rtA181V/T, rtN236T, or rtA194T).
Molecular epidemiology and genotyping of hepatitis B virus of HBsAg-positive patients in Oman.
Discussion: Besides other previously described resistance mutations, the best-described drug resistance mutations are the LAM resistance mutations rtL180M and rtM204V/I and the adefovir resistance mutations rtA181V/T and rtN236T.
Discussion: Other antiviral therapy resistance mutations, such as rtA181V/T or rtN236T, were not detected.
Amino acid polymorphism in the reverse transcriptase region of hepatitis B virus and the relationship with nucleos(t)ide analogues treatment for preventing mother-to-infant transmission.
HBV mutation literature information.
PMID: 
2014
PloS one
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