Abstract: Clonal sequencing was conducted on 192 clones isolated from three patients and showed rtA181T, rtM250V and rtS202G mutations at an overall frequency of 1.54%, 1.39%, and 1.67% respectively.
Multidrug-resistant hepatitis B virus resulting from sequential monotherapy with lamivudine, adefovir, and entecavir: clonal evolution during lamivudine plus adefovir therapy.
Abstract: Among 9 sets of 20 clones obtained during salvage therapy, 39 clones harbored rtA181T/V +- rtN236T mutations, which were detected in the absence of rtM204 and ETV-resistant mutations in 37 clones (94.9%).
Abstract: Only two clones (5.1%) harbored both rtA181T/V and ETV-resistant mutations.
Abstract: The rtA181T/V mutation emerged after reversion from ETV-resistant mutants to wild-type HBV.
Low-level persistence of drug resistance mutations in hepatitis B virus-infected subjects with a past history of Lamivudine treatment.
PMID: 23114756
2013
Antimicrobial agents and chemotherapy
Abstract: Sanger sequencing identified >=1 LAM resistance mutations (rtL80I/V, rtM204I, and rtA181T) in samples from 5 (11%) of 46 LAM-experienced and none of 45 LAM-naive subjects (0%; P = 0.06).
Abstract: UDPS detected >=1 LAM resistance mutations (rtL80I/V, rtV173L, rtL180M, rtA181T, and rtM204I/V) in 10 (22%) of the 46 LAM-experienced subjects, including 5 in whom LAM resistance mutations were not identified by S
Hepatitis B e antigen-suppressing mutations enhance the replication efficiency of adefovir-resistant hepatitis B virus strains.
Abstract: All rtN236T- or rtA181V/T-containing constructs, regardless of concomitant PC or BCP mutations, were resistant to adefovir, but remained susceptible to telbivudine, entecavir and tenofovir.
Abstract: HBV rtA181T mutants displayed abolished hepatitis B surface antigen (HBsAg) secretion, owing to a sW172* stop codon in the overlapping envelope gene.
Abstract: The adefovir-resistant polymerase mutations rtN236T
High frequency of complex mutational patterns in lamivudine resistant hepatitis B virus isolates.
Abstract: Clonal analysis of these seven quasispecies even disclosed the presence of HBV isolates carrying further stop codons and in one case the occurrence of resistance mutation rtA181T without the stop codon mutation sW172*.
Abstract: Interestingly, only one HBV clone carried the resistance mutations rtM204V and rtA181T.
Characterization of antiviral resistance mutations among the Eastern Indian Hepatitis B virus infected population.
Introduction: The primary adefovir-resistant mutations significantly associated with treatment failure are rtN236T and rtA181T/V .
Detection of rtN236T mutation associated with adefovir dipivoxil resistance in Hepatitis B infected patients with YMDD mutations in Tehran.
PMID: 23467016
2013
Iranian journal of microbiology
Abstract: RESULTS: After alignment of protein coding sequences, the rtN236T mutation was observed in two (6.6%) patients, while twenty-eight others had neither rtN236T, nor rtA181V/T mutation.
Abstract: The mutations known as causing adefovir resistance, rtN236T and rt Result: while twenty eight others had neither rtN236T, nor rtA181V/T mutation (Table 2.) Genetic distance was estimated using the Kimura two-parameter matrix and phylogenetic tree was constructed by the neighbor-joining (NJ) method.
Epidemiological, virological and clinical characteristics of HBV infection in 223 HIV co-infected patients: a French multi-centre collaborative study.
Result: ADV resistance rtA181T associated mutations were detected in 5 (2.2%) cases; among those, 3 had never received ADV.
Discussion: Adefovir resistance mutations were exceptionally detected (rtA181T-change in 2.2%) and no change was observed for rtN236.
Discussion: Even if one considers that the rtA181T-strains have a slight decreased sensitivity to TDF, it is reassuring to observe a very low prevalence of ADV-resistance, leaving the opportunity to treat these patients with TDF .
Discussion: The rtA181T or -V change is rarely selected by 3TC treatment and one can not exclude that this was not the case for these patients .
Snapshot on drug-resistance rate and profiles in patients with chronic hepatitis B receiving nucleos(t)ide analogues in clinical practice.
Abstract: Complex mutational patterns characterized by the co-presence of rtM204V/I-rtA181T/V (impairing the efficacy of all anti-HBV drugs) were detected in four patients (2.7%) with virological rebound.
HBV mutation literature information.
PMID: 
2013
Journal of hepatology
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