Discussion: In addition to classical ADV resistance mutations such as rtN236S or rtA181T, a few other related-variants including rtV84I/S, rtL84S, and rtQ215H were identified before VB in patient 1, 3, 4, and 6.
Discussion: In our sequencing data, rtI169L mutation was present in 8%, 1%, and 1% of 100 colonies in patient 1, 3, and 4, as well as rtA181V/T ADV resistance mutations in patient 1 and 4.
Discussion: Regarding HBV quasispecies associated with ADV resistance, the PMID: 23796863
2013
The Journal of infection
Abstract: Indeed, rtS78T (prevalence: 1.1% in drug-naive and 12.2% in adefovir-failing patients) decreased the RT-affinity for adefovir more than the classical adefovir-resistance mutations rtA181 T/V (WT:-9.63 kcal/mol, rtA181T:-9.30 kcal/mol, rtA181V:-7.96 kcal/mol, rtS78T:-7.37 kcal/mol).
Mutation analysis of hepatitis B virus reverse transcriptase region among untreated chronically infected patients in Ahvaz city (South-West of Iran).
PMID: 24064642
2013
Indian journal of medical microbiology
Abstract: Of these, 3 (6.6%) patients had primary resistance mutation (rtM204I, rtA181T and rtA181S) and 20 (44.4%) patients had secondary resistance mutations.
Profile of hepatitis B virus resistance mutations against nucleoside/nucleotide analogue treatment in Chinese patients with chronic hepatitis B.
Introduction: According to previously studies, the patterns of genotypic resistance in the HBV polymerase can be categorized into five specific evolutionary pathways, inc
Result: In this cohort, HBV rtA181T/V mutation was observed in 19.3% (22/114) of patients with LAM/LdT-based therapies and 23.9% (11/46) of patients with ADV-based therapies.
Result: Our findings suggested that rtA181T/V mutations were common among patients with NAs resistance, and it should be regularly monitored in real clinical practice.
Result: Recently, HBV rtA181T/V mutations had been widely concerned and it was regarded to be a multidrug resistance which not only could result in resistance to ADV but also reduce sensitivity to LAM and LdT.
Substitution rtq267h of hepatitis B virus increases the weight of replication and Lamivudine resistance.
Introduction: Substitution rtA181V/T and/or rtN236T can reduce the anti-HBV effect of ADV, rtN238R, rtT240Y and rtN248H of HBV were newly reported to decrease susceptibility to ADV (8).
Hepatitis B virus genotype C encoding resistance mutations that emerge during adefovir dipivoxil therapy: in vitro replication phenotype.
Abstract: CONCLUSIONS: The identification of secretion-defective HBV in the setting of ADV therapy for HBV genotype C, and to a lesser extent HBV genotype B, has major implications for the diagnosis and treatment of HBV in the Asia-Pacific region, as it is likely that quantitative HBsAg and viral load testing of serum from patients infected with HBV encoding rtA181T and rtN236T substitutions may not accurately reflect the level of replication within hepatocytes.
Abstract: Importantly, less HBsAg was detected in the cells transfected with the rtA181T resistance mutants, and the overlapping sW172stop mutation ablated secretion of
An improved reverse dot hybridization for simple and rapid detection of adefovir dipivoxil-resistant hepatitis B virus.
PMID: 22290465
2012
Genetics and molecular research
Abstract: Wedeveloped an improved reverse dot hybridization test for simple and rapiddetection of the rtA181V/T and rtN236T mutations associated with adefovirdipivoxil resistance in chronic hepatitis B patients.
Decreased infectivity of nucleoside analogs-resistant hepatitis B virus mutants.
Abstract: In the LAM+ADV group, patients with single rtN236T resistant mutation had higher rates of undetectable HBV DNA than those with the double mutant rtA181T/V+rtN236T at months 3-18 of therapy.
Abstract: LAM+ADV were less effective in patients with the double mutant rtA181T/V+rtN236T than the single rtN236T mutation.
Abstract: No virological breakthrough occurred except for one patient with rtN236T resistant mutation who experienced virological and biochemical breakthrough a
HBV mutation literature information.
PMID: 
2013
Hepatitis monthly
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