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 HBV mutation literature information.


  Mechanistic characterization and molecular modeling of hepatitis B virus polymerase resistance to entecavir.
 PMID: 20169198       2010       PloS one
Method: Additional HBV-RT homology models were constructed with the LVD (M204V+L180M) and adefovir (A181T/V and N236T) resistance substitutions, and the ETVr signature substitutions T184G & S202I, or M250V were constructed on the LVDr (M204V+L180M) model.


  Establishment of a new quantitative detection approach to adefovir-resistant HBV and its clinical application.
 PMID: 20222172       2010       World journal of gastroenterology
Abstract: Among the 32 clinical patients, single rtA181 and rtN236T mutation and double rtA181T and rtN236T mutations were detected in 20 and 8, respectively, while ADV-resistant mutations in 6 (including, rtA181V/T mutation alone in 5 patients) and no associated mutations in 26.
Abstract: METHODS: Based on the characteristics of rtA181V/T and rtN236T mutations, a new approach based on real-time fluorescent quantitative polymerase chain reaction (RT-PCR) was established for the detection of ADV-resistant HBV quasispecies, to


  Hepatitis B virus drug resistance in HIV-1-infected patients taking lamivudine-containing antiretroviral therapy.
 PMID: 20377434       2010       AIDS patient care and STDs
Abstract: All 19 patients with HBV-DR had lamivudine resistance with the mutations as follows: M204V/I (95%), L180M/A181T (95%), L80V/I (47%), V173L (32%), and N236T (21%).


  [Polymerase region mutations and hepatitis B virus genotypes in chronic hepatitis B patients with poor response to lamivudine].
 PMID: 20380793       2010       Zhonghua gan zang bing za zhi
Abstract: The overall incidence rate of A181V/T mutation in genotype C (5.3%) was significantly higher than that in genotype B (0.4%) (x2=12.23, P less than 0.01), but the incidence rate of M204I/V, L180M, T184A/G/I/S, S202G/I and V173L mutations was not significantly different between genotype B and C (each P more than 0.05).


  Development of HBV S gene mutants in chronic hepatitis B patients receiving nucleotide/nucleoside analogue therapy.
 PMID: 20516567       2010       Antiviral therapy
Abstract: Among them, the rtA181T/sW172* mutant has a dominant negative secretion effect as well as an increased oncogenic potential.


  [Genotype distribution of chronic hepatitis B and hepatitis C patients and investigation of the resistance patterns in hepatitis B cases].
 PMID: 20549958       2010       Mikrobiyoloji bulteni
Abstract: Various mutations were detected in 34.1% (15/44) of CHB patients and these were identified as M2041 (n = 6), Q215S (n = 2), L801 + M2041 (n = 1), L80V + M2041 (n = 1), Q215S + M2041 (n = 1) and M2041 + L180M (n = 1) mutations responsible for LAM resistance; V214A (n = 1) and A181T + N236T (n = 1) mutations responsible for adefovir (ADV) resistance, and V84M + V173L (n = 1) mutation responsible for ADV + LAM resistance.


  National survey of hepatitis B virus (HBV) polymorphism in asymptomatic HBV blood donors from 1999 to 2007 in France.
 PMID: 20553432       2010       Transfusion
Abstract: rtA181T/sW172 stop mutation associated with resistance to nucleos(t)ide analogs was detected in two donors suggesting a transmission of these isolates.


  rtE218G, a novel hepatitis B virus mutation with resistance to adefovir dipivoxil in patients with chronic hepatitis B.
 PMID: 20586936       2010       Journal of viral hepatitis
Abstract: Although three major ADV-resistant mutations of HBV are known, rtA181T/V and rtN236T, HBV mutations associated with ADV resistance have not been fully identified.


  [Detection of HBV resistant mutations related to lamivudine, adefovir and entecavir by reverse hybridization technique].
 PMID: 20587309       2010       Zhonghua gan zang bing za zhi
Abstract: RESULTS: The specific probes of 10 codon positions related to HBV wild-type and resistant reference strains, including I169T, V173L, L180M, A181T, T184G, S202I, M204V, Q215S, N236T, M250V, were distinguished effectively by reverse hybridization method.
Abstract: To detect non-synonymous amino acid substitutions associated with lamivudine, adefovir and entecavir, 26 specific oligonucleotide probes covering ten different codon positions, I169T, V173L/G, L180M, A181T/V,  PMID: 20621632       2010       Digestive and liver disease
Abstract: Drug-resistance mutations were observed in 17 (77.2%) LAM-treated patients with virological breakthrough: 8 M204V, 7 M204I, 1 M204I/V, and 1 A181T.



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