literature

HBV mutation literature information.

Hepatitis B Virus Genotypes and Antiviral Resistance Mutations in Romanian HIV-HBV Co-Infected Patients.

PMID: 35454370 2022 Medicina (Kaunas, Lithuania)

Result: N236T: 28.8% and A181T/V: 15.5%:a profile suggestive for ADV resistance (and associated with reduced susceptibility to TDF/TAF).

Discussion: A relatively high prevalence of the N236T mutation was recorded in the study patients, which is frequently associated with the A181T/V mutation, a combination that confers decreased efficacy of tenofovir in vitro and was linked to a delayed response to TDF/TAF in patients with high viral loads, or with the compensatory L80V mutation, reported to be associated with LAM and ADV resistance.

Discussion: For example, the A181T mutation, also common in this study's patients, was associated with a stop codon in the overlapping portion of the S gene that alters the virion, yet not the subvir

Reactivation of Occult Hepatitis B Virus Infection During Long-Term Entecavir Antiviral Therapy.

PMID: 35359734 2022 Frontiers in microbiology

Table: A181T

Global prevalence and phylogeny of hepatitis B virus (HBV) drug and vaccine resistance mutations.

PMID: 33893696 2021 Journal of viral hepatitis

Method: ETV resistance: Two or more amino acid substitutions are required across the HBV RT protein to confer resistance to ETV which could occur as a combination of M204I/V with one or more of the following substitutions L80I/V, I163V, I169T, V173L, L180M, A181S/T/V, T184X, A186T, S202C/G/I/R, M250I/V and/or C256S/G.

Method: For this analysis, we considered a total of 12 RAMs (S106C/G, D134E,

PMID: 33333207 2021 Journal of hepatology

Abstract: RESULTS: E-CFCP potently blocked HBVWTD1 production (IC50qPCR_cell=1.8 nM) in HepG2.2.15 cells and HBVWTC2 (IC50SB_cell=0.7 nM), entecavir (ETV)-resistant HBVETV-RL180M/S202G/M204V (IC50SB_cell=77.5 nM), and adefovir-resistant HBVADV-RA181T/N236T production (IC50SB_cell=14.1 nM) in Huh7 cells.

High Prevalence of Preexisting HBV Polymerase Mutations in Pregnant Women Does Not Limit the Antiviral Therapy Efficacy.

PMID: 33986897 2021 The Canadian journal of infectious diseases & medical microbiology

Result: RtM204I/V +

Discussion: Furthermore, some pregnant women had multibase mutations combined with rtM204I/V at baseline, including rtM204I + rtA181 T/V, rtM204I/V + rtL80I/V, rtM204I/V + rtN236 T, and rtM204I/V + rtI233 V, which may affect their sensitivity to LAM, TBV, ADV, and TDF.

Detection of Hepatitis B Virus M204V Mutation Quantitatively via Real-time PCR.

PMID: 34007795 2021 Journal of clinical and translational hepatology

Table: A181T

Hepatitis B in the Northwestern region of Sao Paulo State: genotypes and resistance mutations.

PMID: 34755817 2021 Revista do Instituto de Medicina Tropical de Sao Paulo

Result: In the group of patients who were not undergoing treatment, 1.1% (1/90) of the samples presented resistance mutations (rtM204V) to LAM, ADF and FTC, as well as partial resistance to ETV, in addition to a mutation (rtA181T) that confers partial resistance in vitro, but does not imply in vivo resistance to TDF.

Prevalence of Potential Resistance Related Variants Among Chinese Chronic Hepatitis B Patients Not Receiving Nucleos(T)ide Analogues.

PMID: 32765014 2020 Infection and drug resistance

Abstract: Primary and secondary DR variants were found in 7.3% (15/206) of patients, including rtL80I/V, rtI169T

Result: Primary and/or secondary DR variants were found in 7.3% (15/206) of patients, and included rtL80I/V, rtI169T, rtV173L, rtL180M, rtA181T/V, rtM204I/V, and rtN236T.

Table: A181V/T

COLD-PCR Method for Early Detection of Antiviral Drug-Resistance Mutations in Treatment-Naive Children with Chronic Hepatitis B.

PMID: 32708399 2020 Diagnostics (Basel, Switzerland)

Method: All sequences with completely replaced mt were further determined based on an HBV-drug resistance interpretation online tool of Max Planck Institute for Informatics for classical mt, e.g., rtL180M, rtA181V/T, rtT184G/L, rtA194T, rtS202I/G, rtM204I/V, rtN236T, and rtM250I/V, and based on updated references for nonclassical/putative mt, e.g., V207I/M/L,

Impact of Lamivudine-Based Antiretroviral Treatment on Hepatitis B Viremia in HIV-Coinfected South Africans.

PMID: 32545313 2020 Viruses

Abstract: Several lamivudine-associated HBV resistance mutations, including L180M, A181T, M204I, and M204V, were observed.

Result: Analysis of polymerase gene sequences from baseline and follow-up samples showed the presence of resistance-associated mutations in 5 of these 6 patients, including L180M, A181T, M204I, and M204V (Table 5).

Discussion: The current study also detected the M204I variant at baseline in treatment-naive patients, and other mutations such as A181T, L180M, or M204V during follow-up of individuals on a lamiv

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