Abstract: Further analysis showed that the age of G1721A/A1775G/T1858C containing combined mutation group was significantly lower than that of the non-mutation group [(4.58 +- 2.53) years vs.
The mutation of hepatitis B virus and the prognosis of hepatocellular carcinoma after surgery: a pilot study.
PMID: 29628773
2018
Cancer management and research
Method: According to the sequencing outcome, HBV genotype and mutations (including A1752T/G, T1753C, G1757A, A1762T/G1764A, C1766T, T1768A, A1775G, C1799G, A1846T, T1858C, G1896A, G1898A, G1899A, and Pre S deletion) were confirmed by the BLAST analysis (http://blast.ncbi.nlm.nih.gov/Blast.cgi).
Result: According to different mutation regions, A1752T/G, T1753C,
Novel HBV mutations and their value in predicting efficacy of conventional interferon.
PMID: 28381384
2017
Hepatobiliary & pancreatic diseases international
Abstract: In addition, G1721A/A1775G/T1858C combined mutation was associated with higher viral load and lower age distribution.
Discussion: In addition, other combined mutation types such as C1856T/T1858C/
Discussion: In our results, we showed that 16 of 17 T1858C mutation-containing sequences were in T1858C/A1775G/G1721A triple mutations.
Discussion: Statistical analysis demonstrated that the presence of a combined triple-mutation type, G1721A/A1775G/T1858C, was correlated with younger ages, genotype C strains, and a higher DNA load.
[Relationship between hepatitis B virus genotype, BCP/Pre-C region mutations and risk of hepatocellular carcinoma in Guangxi Zhuang Autonomous Region].
PMID: 26564702
2015
Zhonghua liu xing bing xue za zhi
Abstract: A1775G is the protective factor in the development of HCC (OR = 0.192, 95% CI: 0.059-0.622, P = 0.006).
Abstract: CONCLUSION: The present investigation showed that BCP A1762T/G1764A, A1775G and Pre-C T1858C mutations are correlated with the incidence of HCC in Fusui county of Guangxi.
Abstract: The mutation rate of A1775G was significantly higher in control group (28.6%) than in HCC group (13.2%) (P = 0.041).
Longitudinal study on mutation profiles of core promoter and precore regions of the hepatitis B virus genome in children.