Molecular characterization of hepatitis B virus basal core promoter and precore region of isolates from chronic hepatitis B patients.
PMID: 34111075
2021
JPMA. The Journal of the Pakistan Medical Association
Abstract: Classic A1762T/G1764A double mutation was noted in 15(30%) isolates.
Specific determination of hepatitis B e antigen by antibodies targeting precore unique epitope facilitates clinical diagnosis and drug evaluation against hepatitis B virus infection.
Result: In addition, among these patients, 16 were infected with HBV strain harbouring basic core promoter (BCP) mutation A1762T/G1764A, whereas the remaining 45 patients were infected with BCP wild-type strain.
Compartmentalized evolution of hepatitis B virus contributes differently to the prognosis of hepatocellular carcinoma.
Abstract: HBV QC and A1762T/G1764A in the sera and tumors have contrary prognostic effects in HCC.
Abstract: High-frequent A1762T/G1764A in the sera predicted an unfavorable RFS (P < 0.001), whereas, in the tumors, it predicted a favorable RFS (P = 0.035).
Impacts of the Percentage of Basal Core Promoter Mutation on the Progression of Liver Fibrosis After Hepatitis B e Antigen Seroconversion.
PMID: 32860707
2021
The Journal of infectious diseases
Abstract: CONCLUSIONS: The percentage of A1762T/G1764A mutations after HBeAg seroconversion was associated with liver fibrosis.
Abstract: Hepatitis B e antigen seroconversion age is positively correlated with the percentages of A1762T/G1764A mutation at inflammatory phase before HBeAg seroconversion.
Abstract: RESULTS: We demonstrated that the percentages of A1762T/G1764A mutation are significantly higher in subjects with an LSM >7 kPa than in those with an LSM <=7 kPa after HBeAg seroconversion.
Abstract: Subjects who underwent interferon, entecavir, or tenofovir disoproxil
Optimization of the algorithm diagnosis chronic hepatitis B markers in patients with newly diagnosed HIV infection.
Abstract: When analyzing the basal nucleus promoter, Precore and Core regions, 22.2% of patients with the double mutation A1762T / G1764A, 25% with the mutation G1896A were identified.
Quadruple mutation GCAC1809-1812TTCT acts as a biomarker in healthy European HBV carriers.
Abstract: Calculation of the pgRNA secondary structure suggests a destabilization of the pgRNA structure by A1762T/G1764A that was compensated by GCAC1809-1812TTCT.
Abstract: GCAC1809-1812TTCT was strongly associated with coexistence of basal core promoter (BCP) double mutation A1762T/G1764A and lower HBV DNA levels.
Result: An HBV genome was isolated from a serum sample of 1 patient infected with HBV GTA harboring both A1762T/G1764A and GCAC1809-1812TTCT and this genome was cloned as a 1.2-mer into pUC vector.
Result: As described above, GCAC1809-1812TTCT is highly prevalent in inactive carriers and strongly associated with BCP double mutation
LCR based quick detection of hotspot G1896A mutation in patients with different spectrum of hepatitis B.
3Introduction: Both the G1896A and A1762T/G1764A mutations are associated with the ""HBeAg-negative hepatitis"" phase of CHB."
Introduction: HBV X/BCP/PC mutations (i.e., G1896A pre-core and A1762T/G1764A double mutants) are strong predictors of HCC risk and frequently reported in large epidemiological studies of HBV-related HCC.
Introduction: In the current study, we evaluated in vitro the functional properties
Differences in HBV Replication, APOBEC3 Family Expression, and Inflammatory Cytokine Levels Between Wild-Type HBV and Pre-core (G1896A) or Basal Core Promoter (A1762T/G1764A) Mutants.
Result: As expected, HBeAg expression differed with the greatest levels in the wild-type HBV and clearly reduced levels in the A1762T/G1764A double mutant (Figure 1A).
Discussion: However, these in vivo findings are in contrast with our in vitro results in which secreted HBV RNA from the A1762T/G1764A double mutant were not significantly reduced in comparison to the wild-type HBV.
Discussion: Interestingly, the investigators also reported that the presence of BCP mutations (i.e., A1762T/G1764A) correlated to lower levels of serum HBV RNA.
Discussion: The A1762T/G1764A mutations are responsible for the PMID: 32568442
2020
Journal of viral hepatitis
Abstract: rs3135395-T, rs477515-T and rs2395178-G were inversely associated with the generation of A1762T/G1764A, T1753V and C1653T, the HCC-risk HBV mutations.
[Relationship between mutations of HBV basal core promoter region in HBsAg-positive mothers and intrauterine transmission].
PMID: 32564557
2020
Zhonghua liu xing bing xue za zhi
Abstract: Conclusion: A1762T/G1764A double mutations of HBV DNA from the genotype C of those HBsAg-positive mothers could reduced the risk of HBV intrauterine transmission during pregnancy.
Abstract: Maternal A1762T/G1764A double mutations appeared to be possibly associated with neonatal HBeAg (P=0.050).
Abstract: Rates of A1762T/G1764A double mutations were significantly different between the intrauterine transmission group and the control group (7.53% vs.
Abstract: Results from the multivariate analysis showed that the A1762T/G1764A double mutations had reduced the risk of intrauterine transmission (aOR=0.065, 95%CI:
HBV mutation literature information.
PMID: 
2021
JPMA. The Journal of the Pakistan Medical Association
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