Result: The A1762T and G1764A mutations were found in two cases.
Table: A1762T
Discussion: Typically, BCP mutations (A1762T and G1764A) can reduce the mRNA synthesis of the pre-C region, which is reflected as a very low level of HBV DNA.
Transcriptome analysis of hepatoma cells transfected with Basal Core Promoter (BCP) and Pre-Core (PC) mutant hepatitis B virus full genome construct.
PMID: 33595430
2021
The Journal of general virology
Abstract: Infections with Basal Core Promoter (BCP) (A1762T/G1764A) and Pre-Core (PC) (G1896A) hepatitis B virus HBeAg mutants are associated with severe liver injury.
Specific determination of hepatitis B e antigen by antibodies targeting precore unique epitope facilitates clinical diagnosis and drug evaluation against hepatitis B virus infection.
Result: In addition, among these patients, 16 were infected with HBV strain harbouring basic core promoter (BCP) mutation A1762T/G1764A, whereas the remaining 45 patients were infected with BCP wild-type strain.
Compartmentalized evolution of hepatitis B virus contributes differently to the prognosis of hepatocellular carcinoma.
Abstract: HBV QC and A1762T/G1764A in the sera and tumors have contrary prognostic effects in HCC.
Abstract: High-frequent A1762T/G1764A in the sera predicted an unfavorable RFS (P < 0.001), whereas, in the tumors, it predicted a favorable RFS (P = 0.035).
LCR based quick detection of hotspot G1896A mutation in patients with different spectrum of hepatitis B.
Result: Further, an evaluation of APOBEC3G protein levels by immunoblot showed increased amounts in wild type compared to the mock and HBV X/BCP/PC variants (Figure 3A) which was confirmed with densitometry analysis (p-values: vs. mock = 0.0414; vs. G1896A = 0.0205; vs. A1762T/G1764A = 0.0058).
Result: Interestingly, the A1762T/G1764A double mutation HBV has consistently higher levels of supernatant HBV DNA (p-value = 0.0363) and HBV RNA (p-value = 0.0220) in comparison to G1896A HBV variant.
Result: It is interesting to note that both of the X/BCP/PC variants lead to suppression of this cytokine in comparison to wild-type (p-values: vs. G1896A = 0.0509; vs. A1762T/G
Quadruple mutation GCAC1809-1812TTCT acts as a biomarker in healthy European HBV carriers.
Abstract: Calculation of the pgRNA secondary structure suggests a destabilization of the pgRNA structure by A1762T/G1764A that was compensated by GCAC1809-1812TTCT.
Abstract: GCAC1809-1812TTCT was strongly associated with coexistence of basal core promoter (BCP) double mutation A1762T/G1764A and lower HBV DNA levels.
Discussion: As recently described, the BCP double mutation A1762T/G1764A is frequently (61%) found in the overall study population.
Discussion: In our study, we observed a strong association of GCAC1809-1812TTCT with BCP double mutation A1762T/
Optimization of the algorithm diagnosis chronic hepatitis B markers in patients with newly diagnosed HIV infection.
Abstract: When analyzing the basal nucleus promoter, Precore and Core regions, 22.2% of patients with the double mutation A1762T / G1764A, 25% with the mutation G1896A were identified.
Viral hepatitis B and C in HIV-exposed South African infants.
5Result: The ""Week 0"" Cape Town sample showed a similar serological profile to the ""Week 48"" sample from the same child and also had the double A1762T/G1764A BCP mutation."
Abstract: The Result: Both sequences harboured the double A1762T/G1764A BCP mutation.
Result: Sequence analysis revealed the M204I mutation in the reverse transcriptase domain of the polymerase gene in the Durban sample while the Cape Town sample harboured the double A1762T/G1764A BCP mutation in the core gene.
Comprehensive Analysis of Clinically Significant Hepatitis B Virus Mutations in Relation to Genotype, Subgenotype and Geographic Region.
Abstract: HCC-associated mutations were detected in 33.7% of the sequences, with significantly higher frequency of C1653T, T1753V and A1762T/G1764A in genotype G than C (P < 0.001).
Discussion: A previous meta-analysis showed that Pre-S deletions, C1653T in enhancer II, and T1753V and A1762T/G1764A in BCP are associated with increased risk of HCC compared with HBV without mutations.
Discussion: Consistently, genotype H showed the lowest rates of
Case Report: Application of hepatitis B virus (HBV) deep sequencing to distinguish between acute and chronic infection.
HBV mutation literature information.
PMID: 
2021
BMC infectious diseases
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