Mutations of pre-core and basal core promoter before and after hepatitis B e antigen seroconversion.
PMID: 25593470
2015
World journal of gastroenterology
Abstract: METHODS: The proportion of pre-core (G1896A) and basal core promoter (A1762T and G1764A) mutant viruses and serum levels of hepatitis B virus (HBV) DNA, hepatitis B surface antigen (HBsAg), and HB core-related antigen were analyzed in chronic hepatitis B patients before and after HBeAg seroconversion (n = 25), in those who were persistently HBeAg positive (n = 18), and in those who were persistently anti-HBe positive (n = 43).
Clinical utility of complex mutations in the core promoter and proximal precore regions of the hepatitis B virus genome.
Abstract: We previously demonstrated that the accumulation of >= 6 mutations at eight key nucleotides located in these regions (G1613A, C1653T, T1753V, A1762T, G1764A, A1846T, G1896A, and G1899A) is a useful marker to predict the development of HCC regardless of advanced liver disease.
Mutations of Basal core promoter and precore regions in hepatitis B virus genotypes B and C.
Association of Mutations in the Basal Core Promoter and Pre-core Regions of the Hepatitis B Viral Genome and Longitudinal Changes in HBV Level in HBeAg Negative Individuals: Results From a Cohort Study in Northern Iran.
Discussion: In contrast to these findings, cross-sectional studies of HBV viral level and liver disease severity have generally suggested associations with A1762T/G1764A double mutation, although these studies were mostly conducted among participants with other HBV genotypes.
Discussion: Some studies indicated that the A1762T/G1764A mutation typically appears earlier than G1896A during the course of HBV infection.
Lower mutation frequency of BCP/precore regions in e antigen-negative chronic HBV-infected children instead of adults patients.
Discussion: An A1762T/G1764A double mutation in the BCP/precore region would reduce the levels of HBeAg by inhibiting precore mRNA expression, leading to the transition from the immune tolerance to the immune reactive phase, followed by lower DNA viral loads and elevated ALT levels.
Discussion: Deletions in core regions instead of the G1896A and A1762T/G1764A double mutation were observed in early seroconversion processes in a longitudinal study of infants (our own unpublished data), which also supports the idea that HBeAg seroconversion does not solely rely on BCP
Hepatitis B virus genotype distribution and genotype-specific BCP/preCore substitutions in acute and chronic infections in Argentina.
Abstract: In anti-HBe positive chronic infections, sgF1b was more prone to have A1762T/ Introduction: Based on the stability of the encapsidation signal (nt 1847-1907) it has been established that genotypes carrying 1858T (B, C2, C3, D, E, F1 and F4) favor the emergence and selection of G1896A, whereas the double mutation A1762T/G1764A in the BCP is more prone to occur in those genotypes carrying 1858C (A, C1, F2, F3 and H).
Discussion: In vitro studies have shown that mutation A1762T/G1764A does not abrogate HBeAg expression but decreases its levels, while concomitantly increasing viral replication.
Phosphatase and tensin homologue genetic polymorphisms and their interactions with viral mutations on the risk of hepatocellular carcinoma.
Introduction: We and others have reported that HBV mutations C1653T, T1753V, A1762T/G1764A, T1674C/G, and C1766T/T1768A in the enhancer II/basal core promoter (EnhII/BCP) region; G1899A, C2002T, A2159G, A2189C, and G2203A/T in the precore/core region; as well as T53C, PMID: 25926495
2015
Journal of clinical microbiology
Abstract: A triple mutation (A1762T/G1764A/G1896A) was observed more frequently in genotype C than in genotype B.
Hepatitis B virus genotype, mutations, human leukocyte antigen polymorphisms and their interactions in hepatocellular carcinoma: a multi-centre case-control study.
Result: After Bonferroni correction, HBV mutations C1653T, T1674C/G, A1752G, T1753C, A1762T, G1764A, G1899A, and C1969T were still significant associated with HCC risk.
Result: Of those 19 hotspot mutations, C1653T, T1674C/G, A1703G, G1719T, T1727A/G, T1753C, A1762T, G1764A, G1799C,
Virological Characteristics of Acute Hepatitis B in Eastern India: Critical Differences with Chronic Infection.
Abstract: Additionally, among all substitutions, the A1762T and G1764A BCP mutations were the strongest indicators of chronicity.
Result: Major substitutions that were detectable in the BCP/PC region of acute isolates included T1753C (2.7%), A1762T/G1764A (8.1%), A1814C (2.7%), G1896A (10.8%) and G1899A (5.4%).
Discussion: Moreover, we report that the highest difference in entropy was exhibited at positions A1762T and G1764A in the BCP region indicating that these two s
HBV mutation literature information.
PMID: 
2015
World journal of gastroenterology
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