Hepatitis B virus genotype B and mutations in basal core promoter and pre-core/core genes associated with acute-on-chronic liver failure: a multicenter cross-sectional study in China.
Abstract: A multivariate analysis showed that factors such as HBV genotype B, age >=40 years and A1762T/G1764A, A1846T and G1896A mutations were independently associated with the development of HB-ACLF.
Abstract: CONCLUSION: Chronic HBV infection with genotype B, A1762T/G1764A, A1846T a
Abstract: Comparing with CHB-S, the A1762T/G1764A mutation in genotype B and the A2159G mutation in genotype C were significantly more common in HB-ACLF patients.
Effects of genomic changes in hepatitis B virus on postoperative recurrence and survival in patients with hepatocellular carcinoma.
Abstract: RESULTS: The genomic changes such as the G1896A at precore, the A1762T/G1764A at BCP, the C1653T and the T1753V at X gene, and pre-S2 deletion were not significantly associated with postoperative recurrence of HCC or survival of patients after curative resection.
Introduction: The basal core promoter (BCP) gene is a gene frequently changed in HBV as a double mutation (A1762T/G1764T) and has been found to be a codeterminant of PMID: 23112104
2013
Hepatology (Baltimore, Md.)
Abstract: UNLABELLED: Precore (PC) (G1896A) and basal core promoter (BCP) (A1762T/G1764A) mutations of the hepatitis B virus (HBV) genome often emerge in chronic hepatitis B (CHB) patients.
High prevalence of hepatitis B virus genotype C/C1 in the Minangkabau ethnic group in Indonesia.
Introduction: Mutations at the BCP region such as A1762T/G1764A and T1753V were found in high prevalence (59.5% and 40.5%, respectively) and were associated with severe liver disease.
Result: The T1753V mutation was found in 51.9% and 27.4% of the Minangkabau and Javanese ethnic groups (P=0.007), whilst the A1762T/G1764A mutation was detected in 71.2% and 41.9% of the Minangkabau and Javanese ethnic groups (P=0.002) (Table 2).
Result: The mutations A1762T/G1764A and T1753V were found in high prevalence, 35/58 (60.3%) and 21/58 (36.2%) respectively.
New HBV subgenotype D9, a novel D/C recombinant, identified in patients with chronic HBeAg-negative infection in Eastern India.
Abstract: Interestingly, compared to other subgenotypes of HBV/D, D9 isolates had a higher frequency of mutations (A1762T and G1764A) in the basal core promoter region that had been implicated in the development of hepatocellular carcinoma.
Synergistic effects of A1896, T1653 and T1762/A1764 mutations in genotype c2 hepatitis B virus on development of hepatocellular carcinoma.
Abstract: Also, the A1762T/G1764A double mutation may act in synergy with C1653T to increase the risk of HCC in patients chronically infected with HBV genotype C2.
Introduction: One of the most well known mutations in the HBV genome is the basal core promoter (BCP) double mutation that consists of the nucleotide substitution of A to T at position 1762 and of G to A at 1764 (A1762T/G1764A) in the core promoter region.
Discussion: Also, in the present study, the BCP double mutation, A1762T
Interaction of signal transducer and activator of transcription 3 polymorphisms with hepatitis B virus mutations in hepatocellular carcinoma.
Abstract: rs2293152 GG was significantly associated with high viral load (>=1 x 10(4) copies/mL) (AOR, 1.37; 95%, CI 1.01-1.88) and increased frequencies of T1674C/G (AOR, 1.61; 95% CI, 1.06-2.46) and A1762T/G1764A (AOR, 1.64; 95% CI, 1.14-2.35).
Characteristics of hepatitis viruses among Egyptian children with acute hepatitis.
PMID: 23404231
2013
International journal of oncology
Abstract: The A1762T/G1764A double mutation, and the T1846A and G1896A single mutations were common in children with occult HBV infection.
Associations of pri-miR-34b/c and pre-miR-196a2 polymorphisms and their multiplicative interactions with hepatitis B virus mutations with hepatocellular carcinoma risk.
Result: The HBV mutations including T1674C/G, A1762T/G1764A, T1753V, C1653T, and G1896A in the EnhII/BCP/PC as well as preS deletion, preS1 start codon mutation, preS2 start codon mutation, C2875A, A3120G/T, C7A, and C76A in the preS region were significantly associated with an increased risk of HCC, while
Combined core promoter mutations and pre-S deletion of HBV may not increase the risk of HCC: a geographical epidemiological study in Guangxi, China.
Abstract: AIMS: To determine whether the findings that HBV basal core promoter (BCP) A1762T, G1764A double mutations, pre-S deletions and a combination of both are risk factors of HCC are supported by geographical epidemiology.
HBV mutation literature information.
PMID: 
2014
Hepatology international
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