Abstract: Core promoter T1753V, A1762T, and G1764A mutations were more frequent in patients with HCC than in those without, although with no statistical difference.
Combinations of eight key mutations in the X/preC region and genomic activity of hepatitis B virus are associated with hepatocellular carcinoma.
Abstract: Accumulation of eight key mutations located in the X/preC regions of the hepatitis B virus (HBV) genome (G1613A, C1653T, T1753V, A1762T, G1764A, A1846T, G1896A and G1899A) is a risk marker for the development of hepatocellular carcinoma (HCC).
Abstract: Analyses were focused on patient >=40 years of age infected by HBV genotype C with A1762T and G1764A mutations in the basal core promoter region (<
HBx mutants differentially affect the activation of hypoxia-inducible factor-1alpha in hepatocellular carcinoma.
Result: It was particularly interested to find that mutants A1630G and G1721A always appeared concurrently and that mutant A1762T constantly accompanied mutant G1764A.
Result: The dual mutations at nucleotides A1762T/G1764A affected the codons of HBx, resulting in a lysine to methionine change at codon 130 and a valine to isoleucine change at codon 131 (K130M/V131I).
Result: Therefore, these findings indicated that the dual point mutations A1762T/G1764A, which result in mutated K130M/<
Detection of hepatitis B virus A1762T/G1764A mutant by amplification refractory mutation system.
PMID: 24389280
2014
The Brazilian journal of infectious diseases
Abstract: However, the percentage of A1762T/G1764A double mutation in hepatitis B e antigen-negative (58.3%) samples was almost the same as in hepatitis B e antigen-positive (61%) samples.
Abstract: METHODS: We developed an accurate and fast real-time amplification refractory mutation system to detect A1762T/G1764A double mutation.
Abstract: OBJECTIVE: To study the role of hepatitis B virus with A1762T/G1764A double mutation in liver cirrhosis and hepatocellular carcinoma, and create a sensitive, fast, accurate assay for detection of A1762T/
Molecular characterization of HBV strains circulating among the treatment-naive HIV/HBV co-infected patients of eastern India.
Abstract: The major mutations affecting HBeAg expression includes the A1762T/G1764A (13.6%), G1896A (22%) and G1862T mutation (33.9%) which was predominantly associated with HBV/A1.
Result: A total of 8 isolates (8/59, 13.6%) harbored the BCP (A1762T/G1764A) double mutations.
Result: Interestingly, all the subjects with PreS1 or PreS2 deletion had A1762T/G1764A mutation in their BCP region whereas the G1896A PC mutation was found i
Analysis of complete nucleotide sequences of Angolan hepatitis B virus isolates reveals the existence of a separate lineage within genotype E.
Result: The common variations A1762T-G1764A in the basal core promoter and G1896A and G1899A in the precore region were identified in three, four and two isolates, respectively.
Table: A1762T
Mutation profiling of the hepatitis B virus strains circulating in North Indian population.
Discussion: K130M and V131I are translated due to basal core promoter mutations Adenine to Threonine at nucleotide position 1762 (A1762T) and Guanosine to Adenine at nucleotide position 1764 (
Discussion: However, quarter of HBeAg negative isolates has genotype A (A1762T and G1764A) HBV infection (Basal Core Promoter mutation)
Discussion: However, quarter of HBeAg negative isolates has genotype A (A1762T and G1764A) HBV infection (Basal Core Promoter mutation).
Novel natural mutations in the hepatitis B virus reverse transcriptase domain associated with hepatocellular carcinoma.
Introduction: A recent meta-analysis including a total of 11,582 HBV-infected participants revealed that deletions in the pre-S gene and mutations of C1653T, T1753V and A1762T/G1764A in the basal core promoter (BCP)/enhancer II (EnhII) region had statistically significant summary odds ratios (OR) for HCC.
Molecular epidemiological study of hepatitis B virus genotypes in Southwest, China.
Abstract: 67.5% (56/83) of genotype C/D was Hepatitis B surface antigen (HBsAg) positive/Hepatitis B e antigen (HBeAg) positive/HBV DNA>=20,000 IU/ml, BCP A1762T/G1764A double mutation was frequent in genotype C and C/D, and G1896A was frequent in B and B/C.
Abstract: C/D recombinant exhibits higher frequency with HBeAg positive, high level of HBV DNA and BCP A1762T/G1764A double mutation.
Abstract: HBV infectious markers, HBV DNA and mutations in the basic core promoter (BCP) <
Mother-to-child transmission of hepatitis B virus: evolution of hepatocellular carcinoma-related viral mutations in the post-immunization era.
Abstract: In the 56 mother-child pairs with 1-15 year-old children acquired the infection from their mothers, the frequencies of HBV mutations including A1762T/G1764A and G1896A in genotype B2 or C2 increased consecutively with increasing age of children.
Abstract: The HCC-risk mutations including A1762T/G1764A were present in the mothers' and cord blood but mostly absent in the 7-month-old infants'.
Abstract: These mutations including A1762T/G1764A in genotype C2 and G1896A in genotype B2 were more frequent in mothers than in children (P<0.001).
HBV mutation literature information.
PMID: 
2014
Journal of medical virology
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