literature

Hepatitis B Virus Combo Mutations Improve the Prediction and Active Prophylaxis of Hepatocellular Carcinoma: A Clinic-Based Cohort Study.

PMID: 26290395 2015 Cancer prevention research (Philadelphia, Pa.)

Abstract: In control patients carrying A1762T/G1764A, addition of C1653T and/or T1753V significantly increased HCC risk (HR, 1.57; P = 0.038); combo mutations with C1653T, T1753V, and A1762T/G1764A improved the validity of HCC prediction by age, male, and cirrhosis (P = 0.002).

Abstract: In summary, HBV mutation A1762T/G1764A, C1653T, and T1753V in combination improve

PMID: 26447624 2015 Zhonghua gan zang bing za zhi

Abstract: CONCLUSION: Incidence of the T1674C mutation in the X region and of the T1753C mutation and the A1762T/G1764A double mutation in the BCP region was higher for patients with HBV-related HCC; the T1753C mutation and the A1762T/G1764A double mutation may inhibit the formation of HBeAg.

Abstract: Prevalence of the T1753C mutation and the A1762T/G1764A double mutation in the BCP region was significantly higher in the

PMID: 26543337 2015 Chinese journal of cancer research

Abstract: CONCLUSIONS: This study demonstrated that PreS mutations, C1653T, T1753V, and A1762T/G1764A, were associated with an increased risk of HCC.

Abstract: For mutations in BCP, statistically significant pooled-RRs of HCC were obtained for T1753V (pooled-RR=2.09; 95% CI: 1.49-2.94) and A1762T/G1764A double mutations (pooled-RR=3.11; 95% CI: 2.08-4.64).

[Relationship between hepatitis B virus genotype, BCP/Pre-C region mutations and risk of hepatocellular carcinoma in Guangxi Zhuang Autonomous Region].

PMID: 26564702 2015 Zhonghua liu xing bing xue za zhi

Abstract: CONCLUSION: The present investigation showed that BCP A1762T/G1764A, A1775G and Pre-C T1858C mutations are correlated with the incidence of HCC in Fusui county of Guangxi.

Abstract: Multiple logistic regression analysis indicated that A1762T/G1764A and T1858C mutations are the risk factors for the development of HCC (OR = 5.459, 95% CI: 1.397-21.332, P = 0.015; OR = 3.881, 95% CI: 1.462-10.305, P = 0.006).

Abstract: RESULTS: The mutation rates of the A1762T/

Hepatitis B virus genotype, mutations, human leukocyte antigen polymorphisms and their interactions in hepatocellular carcinoma: a multi-centre case-control study.

PMID: 26568165 2015 Scientific reports

Result: After Bonferroni correction, HBV mutations C1653T, T1674C/G, A1752G, T1753C, A1762T, G1764A, G1899A, and C1969T were still significant associated with HCC risk.

Result: Of those 19 hotspot mutations, C1653T, T1674C/G, A1703G, G1719T, T1727A/G, T1753C, A1762T, G1764A, G1799C,

Deep sequencing of hepatitis B virus basal core promoter and precore mutants in HBeAg-positive chronic hepatitis B patients.

PMID: 26647737 2015 Scientific reports

Abstract: G1719T, T1753V, A1762T and G1764A were genotype C related.

Abstract: BCP A1762T/G1764A double mutants were generally accompanied with PC 1896 wild type or lower PC G1896A mutant percentage.

Abstract: Lower serum HBeAg and HBsAg levels were associated with higher BCP A1762T/G1764A mutant percentages (>= 50%).

Chronic hepatitis B in pregnant women: is hepatitis B surface antigen quantification useful for viral load prediction?

PMID: 26571304 2015 International journal of infectious diseases

Abstract: Two-thirds of HBeAg-negative subjects with high HBV DNA levels harboured BCP (A1762T/G1764A) and/or PC (G1896A) variants.

Virological Characteristics of Acute Hepatitis B in Eastern India: Critical Differences with Chronic Infection.

PMID: 26571502 2015 PloS one

Abstract: Additionally, among all substitutions, the A1762T and G1764A BCP mutations were the strongest indicators of chronicity.

Result: Major substitutions that were detectable in the BCP/PC region of acute isolates included T1753C (2.7%), A1762T/G1764A (8.1%), A18

Discussion: Moreover, we report that the highest difference in entropy was exhibited at positions A1762T and G1764A in the BCP region indicating that these two sites were most susceptible towards acquiring mutations, thus signifying that they were the strongest indicators of chronicity.

Mother-to-child transmission of hepatitis B virus: evolution of hepatocellular carcinoma-related viral mutations in the post-immunization era.

PMID: 24973814 2014 Journal of clinical virology

Abstract: In the 56 mother-child pairs with 1-15 year-old children acquired the infection from their mothers, the frequencies of HBV mutations including A1762T/G1764A and G1896A in genotype B2 or C2 increased consecutively with increasing age of children.

Abstract: The HCC-risk mutations including A1762T/G1764A were present in the mothers' and cord blood but mostly absent in the 7-month-old infants'.

Abstract: These mutations including A1762T/G1764A in genotype C2 and G1896A in genotype B2 were more frequent in mothers than in children (P<0.001).

Variability in the precore and core promoter region of the hepatitis B virus genome.

PMID: 24249691 2014 Journal of medical virology

Abstract: The study confirmed that core promoter and precore mutations occur at key positions (A1762T, G1764A, G1896A, and G1899A), and that the proportions of strains with seroconvertion in patients differ between the four HBV genotypes.