literature

HBV mutation literature information.

Clinical utility of complex mutations in the core promoter and proximal precore regions of the hepatitis B virus genome.

PMID: 25625002 2015 World journal of hepatology

Abstract: We previously demonstrated that the accumulation of >= 6 mutations at eight key nucleotides located in these regions (G1613A, C1653T, T1753V, A1762T, G1764A, A1846T, G1896A, and G1899A) is a useful marker to predict the development of HCC regardless of advanced liver disease.

Mutations of Basal core promoter and precore regions in hepatitis B virus genotypes B and C.

PMID: 25741368 2015 Hepatitis monthly

Table: A1762T

Association of Mutations in the Basal Core Promoter and Pre-core Regions of the Hepatitis B Viral Genome and Longitudinal Changes in HBV Level in HBeAg Negative Individuals: Results From a Cohort Study in Northern Iran.

PMID: 25788956 2015 Hepatitis monthly

Discussion: In contrast to these findings, cross-sectional studies of HBV viral level and liver disease severity have generally suggested associations with A1762T/G1764A double mutation, although these studies were mostly conducted among participants with other HBV genotypes.

Discussion: Some studies indicated that the A1762T/G1764A mutation typically appears earlier than G1896A during the course of HBV infection.

Lower mutation frequency of BCP/precore regions in e antigen-negative chronic HBV-infected children instead of adults patients.

PMID: 25822176 2015 PloS one

Discussion: An A1762T/G1764A double mutation in the BCP/precore region would reduce the levels of HBeAg by inhibiting precore mRNA expression, leading to the transition from the immune tolerance to the immune reactive phase, followed by lower DNA viral loads and elevated ALT levels.

Discussion: Deletions in core regions instead of the G1896A and A1762T/G1764A double mutation were observed in early seroconversion processes in a longitudinal study of infants (our own unpublished data), which also supports the idea that HBeAg seroconversion does not solely rely on BCP

Hepatitis B virus genotype distribution and genotype-specific BCP/preCore substitutions in acute and chronic infections in Argentina.

PMID: 25822666 2015 PloS one

Result: In brief, those patients infected with sgF4 and gD mutated G1896A more frequently than A1762T/G1764A (p = 0.007 and p<0.001 respectively), whereas those patients carrying sgF1b and sgA2 had the opposite mutation pattern, showing higher rates of mutations in positions 1762 and 1764 than in 1896 (p = 0.013 and p = 0.010 respectively).

Result: In spite of the low prevalence of mutations in AHB infections (25.7%), those subgenotypes more frequently observed in this stage, sgA2 and sgF1b, had the double mutation A1762T/G1764A, while gD and sgF4 did not mutate these positions (Table 3).

Result: The double mutation A1762T/G176

Phosphatase and tensin homologue genetic polymorphisms and their interactions with viral mutations on the risk of hepatocellular carcinoma.

PMID: 25881591 2015 Chinese medical journal

Introduction: We and others have reported that HBV mutations C1653T, T1753V, A1762T/G1764A, T1674C/G, and C1766T/T1768A in the enhancer II/basal core promoter (EnhII/BCP) region; G1899A, C2002T, A2159G, A2189C, and G2203A/T in the precore/core region; as well as T53C,

PMID: 25926495 2015 Journal of clinical microbiology

Abstract: A triple mutation (A1762T/G1764A/G1896A) was observed more frequently in genotype C than in genotype B.

Hepatitis B virus genotype, mutations, human leukocyte antigen polymorphisms and their interactions in hepatocellular carcinoma: a multi-centre case-control study.

PMID: 26568165 2015 Scientific reports

Result: After Bonferroni correction, HBV mutations C1653T, T1674C/G, A1752G, T1753C, A1762T, G1764A, G1899A, and C1969T were still significant associated with HCC risk.

Result: Of those 19 hotspot mutations, C1653T, T1674C/G, A1703G, G1719T, T1727A/G, T1753C, A1762T, G1764A, G1799C,

Virological Characteristics of Acute Hepatitis B in Eastern India: Critical Differences with Chronic Infection.

PMID: 26571502 2015 PloS one

Abstract: Additionally, among all substitutions, the A1762T and G1764A BCP mutations were the strongest indicators of chronicity.

Result: Major substitutions that were detectable in the BCP/PC region of acute isolates included T1753C (2.7%), A1762T/G1764A (8.1%), A18

Discussion: Moreover, we report that the highest difference in entropy was exhibited at positions A1762T and G1764A in the BCP region indicating that these two sites were most susceptible towards acquiring mutations, thus signifying that they were the strongest indicators of chronicity.

Chronic hepatitis B in pregnant women: is hepatitis B surface antigen quantification useful for viral load prediction?

PMID: 26571304 2015 International journal of infectious diseases

Abstract: Two-thirds of HBeAg-negative subjects with high HBV DNA levels harboured BCP (A1762T/G1764A) and/or PC (G1896A) variants.

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