A new hepatitis B virus e antigen-negative strain gene used as a reference sequence in an animal model.
PMID: 29339154
2018
Biochemical and biophysical research communications
Abstract: The main four point variants including A1762T, G1764A, G1896A, and G1899A were detected in the full-length genome.
Abstract: The strain will increase viral replication and infection for mutations A1762T and G1764A in the basal core promoter region, and mutations G1896A and G1899A in the pre-core region.
Analysis of HBV basal core promoter/precore gene variability in patients with HBV drug resistance and HIV co-infection in Northwest Ethiopia.
Abstract: RESULTS: Among the major mutant variants detected, double BCP mutations (A1762T/G1764A) (25.9%), Kozak sequences mutations (nt1809-1812) (51.7%) and the classical PC mutations such as A1814C/C1816T (15.4%), G1896A (25.2%) and G1862T (44.8%) were predominant mutant variants.
Discussion: As the result of BCP polymorphism, clinically important multiple mutations per a study subject; such as T1753V/A1762T/G1764A and A1762T/G1764A/C1766T (or
Molecular characterization of hepatitis B virus X gene in HIV-positive South Africans.
Abstract: The basal core promoter mutations T1753C, A1762T, and G1764A were identified in the majority of sequences.
Development of a fibrosis index including hepatitis B virus basal core promoter A1762T mutation for pretherapeutic evaluation.
PMID: 29424069
2018
Journal of gastroenterology and hepatology
Abstract: A fibrosis score including Anti-hepatitis B e antibody, Basal core promoter (BCP) A1762T mutation, and Platelet count Index (named ABPI) was derived from the modeling cohort.
Abstract: CONCLUSIONS: We developed a transaminase-free fibrosis score (ABPI) utilizing basal core promoter A1762T data, which outperformed APRI and FIB-4.
Qidong hepatitis B virus infection cohort: a 25-year prospective study in high risk area of primary liver cancer.
Introduction: By using the plasma samples from the members of the QBC, we found the A1762T/G1764A double mutation of the HBV basal core promoter (BCP) was frequently detected in HBV infected participants.
Introduction: However, the A1762T/G1764A double mutation alone was not sufficient to produce a statistically significant association with PLC.
Introduction: While A1762T/G1764A, C1653T, A799G, A987G, T1055A, pre-S deletion could be detected in the plasma long before P
The mutation of hepatitis B virus and the prognosis of hepatocellular carcinoma after surgery: a pilot study.
PMID: 29628773
2018
Cancer management and research
Introduction: The A1762T/G1764A BCP double mutation was associated with a hazard ratio (HR) of 1.73 for developing HCC.
Introduction: The most frequent BCP mutation is a double mutation involving an A to T substitution at nucleotide 1762 and a G to A substitution at nucleotide 1764.
Method: According to the sequencing outcome, HBV genotype and mutations (including A1752T/G, T1753C, G1757A, A1762T/G1764A, C1766T, T1768A, PMID: 29804376
2018
Zhonghua gan zang bing za zhi
Abstract: For 49 cases of HBeAg-negative patients, HBV B, C, B and C were mixed before tenofovir dipivoxil treatment, and C1653T, A1762T and G1764A mutation sites were detected in patients with D genotype.
BCP/PC mutation prevalence and their association with HBV replication in HIV/HBV co-infected patients.
Abstract: All the 12 HCC-associated SNVs proved by meta-analysis were confirmed by NGS analysis, except for C1766T and T1768A which were mainly expressed in genotypes A and D, but including the subgroup analysis of A1762T.
The Effect of ICOS Polymorphism Interactions with HBV Mutations on HBV Subtype Infection Outcomes.
1Abstract: Further study indicated that interactions between ICOS rs10932029 genotype ""TC"" and A1762T or A1762T/G1764A mutations significantly decreased the LC risk in the genotype C group."
1Abstract: The interactions between the rs10932029 genotype ""TC"" and A1762T or A1762T/G1764A mutations could decrease the risk of LC."
Abstract: Additionally, the A1762T, G1764A and A1762T/G1764A mutations were associated with an increased risk of LC in the genotype C group.
HBV mutation literature information.
PMID: 
2018
Biochemical and biophysical research communications
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