Basal core promoter and precore mutations among hepatitis B virus circulating in Brazil and its association with severe forms of hepatic diseases.
PMID: 28902288
2017
Memorias do Instituto Oswaldo Cruz
Result: HCC and cirrhosis were found to be associated with the presence of the A1762T/G1764A mutant (OR = 5.42
Result: An association between infection with the HBV A1762T/G1764A BCP mutant and the presence of moderate and severe fibrosis, clinically detected hepatic cirrhosis, and the presence of HCC was verified in this study.
Result: HBV strains with BCP mutations, the most frequent being the A1762T/G1764A double mutation, were detected in 59.3% (70/118) of the patients studied.
Chronic hepatitis B carriers with acute on chronic liver failure show increased HBV surface gene mutations, including immune escape variants.
Conclusion: Interestingly, the G1896A and A1762T/G1764A mutations, although associated with fulminant hepatitis B development in other studies, were found at low frequency in ACLF patients compared to non-ACLF/HBeAg negative hepatitis CHB patients.
Figure: a The incidence of A1762T/G1764A dual mutations was significantly higher in HBeAg negative hepatitis group than in both HBeAg positive (****p < 0.0001) and HBeAg negative ACLF-CHB groups (****p < 0.0001) and immun
Patients with Coexistence of Circulating Hepatitis B Surface Antigen and Its Antibody May Have a Strong Predisposition to Virus Reactivation During Immunosuppressive Therapy: A Hypothesis.
Abstract: DNA sequencing analysis of the HBV genome revealed triple mutations (A1762T, G1764A, and T1753V) in the BCP region, which could further enhance the ability of HBV replication.
Abstract: Recent studies have shown that the uncommon serological pattern of coexistent circulating HBV surface antigen (HBsAg) and its antibody (anti-HBs) was associated with double mutations (A1762T/G1764A) in the basal core promoter (BCP) region of the HBV genome, which is critical for HBV replication.
Introduction: Coexistence of circulating HBsAg and anti-
Analyses of the Genetic Diversities and Mutations of the Hepatitis B Virus Genome BCP/Pre C Region.
Abstract: Other mutations in descending order by mutation rate were a: A1762T/G1764A combined mutation (90. 48%); G1756C/T1803A/A(1757 ~ 1765)/A (1824 ~ 1832) combined mutation (80. 95%); T1753C/A1762T/ G1764A combined mutation (57. 14%); A1762T/G1764A/G1896A combined mutation (42. 86%); G1756C/_(1757~176.5) combined mutation,(28. 57%); T1753C/A1762T/G1764A/G1896A combined mutation (23. 81%).
Differences in HBV Replication, APOBEC3 Family Expression, and Inflammatory Cytokine Levels Between Wild-Type HBV and Pre-core (G1896A) or Basal Core Promoter (A1762T/G1764A) Mutants.
PMID: 28606415
2017
The Brazilian journal of infectious diseases
Abstract: A total of 49 patients with chronic hepatitis B were included in the study, and the HBV A1762T/G1764A double mutant strain was detected in four samples (8.16%) by polymerase chain reaction followed by restriction fragment length analysis (PCR-RFLP).
Abstract: In this study, 75% of the samples with the HBV A1762T/G1764A double mutation were HBeAg negative and anti-HBe positive, reflecting seroconversion even though they still displayed high viral loads.
Abstract: Mutant HBV strains, such as the HBV A1762T/G1764A double mutant, have been associated with poor prognosis and higher risk of the patient for developing
Associations between serum HBX quasispecies and their integration in hepatocellular carcinoma.
PMID: 31966550
2017
International journal of clinical and experimental pathology
Abstract: In these, the HBX-integrated groups had significantly higher mutation frequencies at C1497T, A1630G, G1721A, A1762T/G1764A and A1774G.
Hepatitis B virus mutations, expression quantitative trait loci for PTPN12, and their interactions in hepatocellular carcinoma.
Result: Of those 19 hotspot mutations, C1653T, T1674C/G, A1703G, G1719T, T1727A/G, T1753C, A1762T, G1764A, G1799C, G1899A,
Discussion: A1762T, G1764A, and T1753C/A mutations in the BCP region, and G1613A and C1653T mutations in the Enh II region were reported more frequent in HCC patients 27.
Predictors of hepatitis B e antigen-negative hepatitis in chronic hepatitis B virus-infected patients from childhood to adulthood.
Abstract: HBeAg-negative hepatitis subjects carried more A1762T/G1764A, C2063A, and A2131C HBV gene mutations than those without HBeAg-negative hepatitis.
Hepatitis B virus basal core promoter/precore mutants and association with liver cirrhosis in children with chronic hepatitis B virus infection.
PMID: 26577140
2016
Clinical microbiology and infection
Abstract: Among all the patients with genotype C viruses, the patients with LC had higher prevalence of C1653T, A1762T/G1764A and G1896A mutation frequency, higher hepatitis B e antigen (HBeAg) -negative rates, lower viral load, lower elevated alanine aminotransferase and lower anti-HBe positive rates than CHB patients.
Abstract: Patients with HBV genotype C viruses, high viral load and C1653T, A1762T/G1764A, G1896A mutant viruses, were more susceptible to developing PMID: 26764909
2016
PloS one
Method: Finally, A1762T/G1764A mutations in BCP region and T1858C, G1862C andG1896A mutations in PC region were analyzed.
Result: One HBV/A strain (1/8, 12.5%) had BCP mutations whereas three (3/6, 50%) HBV/E strains showed the A1762T and G1764A double mutation (P = .35) (Table 2).
HBV mutation literature information.
PMID: 
2017
Memorias do Instituto Oswaldo Cruz
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