Abstract: In addition, 63% genotype A and 33% genotype D strains had the basal core promoter mutations, A1762T/G1764A.
The nucleotide changes within HBV core promoter/precore during the first 12weeks of nucleos(t)ide treatment might be associated with a better virological response.
PMID: 28088502
2017
Infection, genetics and evolution
Abstract: The mutation rates of A1762T/G1764A and G1896A were found to decrease from 46.2% (24/52) at baseline to 36.5% (19/52) at week 12 (P=0.426) and from 28.8% (15/52) to 21.2% (11/52) (P=0.497), respectively.
Clinical features and viral quasispecies characteristics associated with infection by the hepatitis B virus G145R immune escape mutant.
Result: With regard to the 'hot-spot' mutations in the HBV genome, G1896A in the preC region and A1762T/G1764A in the basic core promoter region were studied.
Sequence analysis and functional characterization of full-length hepatitis B virus genomes from Korean cirrhotic patients with or without liver cancer.
Result: All the high replicating clones harbored A1762T/ G1764A mutations, and all but the three non-HCC clones harbored G1896A precore mutation.
Result: Consistent with the high prevalence of core promoter mutations in genotype C, especially at the advanced stages of liver diseases, 34 of the 36 clones (including all the 20 HCC-derived clones) harbored the A1762T/G1764A double mutation.
Result: Finally, the only two clones lacking A1762T/G1764A mutations (12.1 and 12.3 from a non-
Hepatitis B virus sequencing and liver fibrosis evaluation in HIV/HBV co-infected Nigerians.
PMID: 28376292
2017
Tropical medicine & international health
5Result: Fifteen (43%) had the double A1762T/G1764A mutation (""TA mutation"") in the BCP region; an additional patient had only G1764A."
8Discussion: The double A1762T/G1764A (""TA"" mutation) in the BCP region affects mRNA transcription and decreases HBeAg production."
Abstract: We identified BCP A1762T/G1764A in 15/35 (43%), PC G1896A in 20/35 (57%), 'a' determinant mutations in 12/45 (26.7%) and preS2 deletions in 6/16 (37.5%)
Complete genome sequencing and clinical analysis of intrahepatic hepatitis B virus cccDNA from HCC.
Abstract: A meta-analysis of pooled results from case-control studies examined the association between mutations G1896A, A1762T, G1764A, and A1762T/G1764A and the risk of HCC.
Abstract: CONCLUSION: In summary, we found that G1896A, A1762T, G1764A, and A1762T/G1764A are associated with an increased risk of HCC.
Abstract: RESULTS: We included 29 articles for analysis and found that G1896A (summary odds ratios [OR] = 2.04, 95% confidence interval [CI] = 1.41-2.95), HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism.
Abstract: Hepatitis B virus (HBV) genomic mutations A1762T, G1764A and AG1762/1764TA cause production of HBV X protein (HBx) mutants, namely K130M, V131I and KV130/131MI.
Clustering infection of hepatitis B virus genotype B4 among residents in Vietnam, and its genomic characters both intra- and extra-family.
Result: There were no C1653T mutations, two (4.5%) T1753V mutations, five (11.4%) double mutations of A1762T/
Discussion: But looking at the promoter region mutations, G1613A mutation was identified in 10.3% of these 31 strains, C1653T was 0%, T1753V was 3.2%, A1762T/G1764A was 16.1%, and C1766T /T1768A was 3.2%.
Discussion: Reported promoter mutations are G1613A, C1653T, and T1753V single mutations and A1762T/G1764A double mutations.
Natural history of acute and chronic hepatitis B: The role of HBV genotypes and mutants.
PMID: 28774406
2017
Best practice & research. Clinical gastroenterology
Abstract: In chronic hepatitis B patients, genotype C and D have a higher frequency of basal core promoter A1762T/G1764A mutations than genotype A and B.
HBV mutation literature information.
PMID: 
2017
Journal of viral hepatitis
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