The genetic polymorphism down-regulating HLA-DRB1 enhancer activity facilitates HBV persistence, evolution and hepatocarcinogenesis in the Chinese Han population.
Abstract: rs3135395-T, rs477515-T and rs2395178-G were inversely associated with the generation of A1762T/G1764A, T1753V and C1653T, the HCC-risk HBV mutations.
[Relationship between mutations of HBV basal core promoter region in HBsAg-positive mothers and intrauterine transmission].
PMID: 32564557
2020
Zhonghua liu xing bing xue za zhi
Abstract: Conclusion: A1762T/G1764A double mutations of HBV DNA from the genotype C of those HBsAg-positive mothers could reduced the risk of HBV intrauterine transmission during pregnancy.
Abstract: Maternal A1762T/G1764A double mutations appeared to be possibly associated with neonatal HBeAg (P=0.050).
Abstract: Rates of A1762T/G1764A double mutations were significantly different between the intrauterine transmission group and the control group (7.53% vs.
Abstract: Results from the multivariate analysis showed that the A1762T/G1764A double mutations had reduced the risk of intrauterine transmission (aOR=0.065, 95%CI:
Complete genome analysis of hepatitis B virus in Qinghai-Tibet plateau: the geographical distribution, genetic diversity, and co-existence of HBsAg and anti-HBs antibodies.
Result: In the level of nucleotide, the double mutations A1762T/G1764A in the BCP region of HBV (nt1742-1849) were frequently observed in HBV/CD sequences (50/179, 27.9%).
Table: A1762T
Discussion: In this study, the A1762T/G1764A double mutations were observed in 27.93% in HBV CD recombinant sequences.
Discussion: Previous studies reported that A1762T/G1764A double mutation in BCP (nt.1742-1849) was the strongest viral factor associated with the development of liver disease.
In silico Analysis of Genetic Diversity of Human Hepatitis B Virus in Southeast Asia, Australia and New Zealand.
Abstract: The three HBV variants identified most frequently were p.V5L, c.1896G>A and double mutation c.1762A>T/c.1764G>A, while genotypes B and C had the widest range of mutation types.
The genetic variability of hepatitis B virus subgenotype F1b precore/core gene is related to the outcome of the acute infection.
Abstract: Mutations T1753C, A1762T, G1764A, C1766T, T1768A G1896A, G2092T and T2107C were associated with acute liver failure and progression to chronic hepatitis.
High possibility of hepatocarcinogenesis in HBV genotype C1 infected Cambodians is indicated by 340 HBV C1 full-genomes analysis from GenBank.
Result: In details, patterns 1 to 9 represented combination mutation at C1653T and A1762T/G1764A (32/340 9.4%), patterns 10 and 11 at C1653T or T1753V and A1762T/G1764A (4/340 1.25%), and patterns 12 to 23 at T1753V and A1762T/G1764A (77/340 22.6%).
Result: In patterns 24 to 32, 47 strains of double mutation at A1762T/G1764A were recognized (47/340 13.8%).
Result: Of these, five at C1653T and A1762T/G1764A and nine at
rt269I Type of Hepatitis B Virus (HBV) Leads to HBV e Antigen Negative Infections and Liver Disease Progression via Mitochondrial Stress Mediated Type I Interferon Production in Chronic Patients With Genotype C Infections.
Result: In double mutations in BCP, only the G1764A mutation, but not the A1762T, was significantly prevalent in patients with rt269I of both our cohort and GenBank.
Result: Of the various HBV mutations, G1896A mutations on the pre-core region (preC mutation) and A1762T/G1764A double mutations on the basal core promoter (BCP) lead to HBeAg negative infection that are significantly related to liver disease progression.
Table: A1762T
Next generation sequencing identifies baseline viral mutants associated with treatment response to pegylated interferon in HBeAg-positive chronic hepatitis B.
Abstract: Based on NGS, the prevalence of T1753V (T1753C/A/G) and A1762T/G1764A variants were significantly lower in responders compared to non-responders (8.3% vs.
Abstract: The absence of T1753V and A1762T/G1764A mutations were factors associated with CR (OR 11.65, 95%CI 1.36-100.16, P = 0.025, and OR 4.36, 95%CI 1.08-17.63, P = 0.039, respectively).
Abstract: The existence of pre-treatment T1753V, A1762T/G1764A mutations and their combination yielded negative predictive values of 94.7%, 85.7% and 93.8%, respectively.
Locus 5p13.1 may be associated with the selection of cancer-related HBV core promoter mutations.
PMID: 31341412
2019
International journal of medical sciences
Abstract: Background: The basal core promoter (BCP) double mutations (A1762T and G1764A) of hepatitis B virus (HBV) have been reported to be an aetiological factor of hepatocellular carcinoma (HCC).
Introduction: The precore mutation (G1896A), mutations in Discussion: In summary, our study provides evidence using GWAS that host genetic polymorphisms are associated with the immune selection of HCC-related double mutations (A1762T and G1764A) in the basal core promoter of HBV.
Large-scale viral genome analysis identifies novel clinical associations between hepatitis B virus and chronically infected patients.
Discussion: Previous studies described additional variants in the core promoter including C1653T, T1753C, A1762T, and G1764A and their correlation with the downregulation of precore mRNA.
Discussion: While our study did not identify any significant association with A1762T and G1764A, we found T1753C to be strongly associated with HBeAg status in our dataset (Supplementary Table 2).
HBV mutation literature information.
PMID: 
2020
Journal of viral hepatitis
Browser Board
Co-occurred Entities
Filtrator
ViMRT