Discussion: mutations which were absent in the current study, TA1 to TA3 rich BCP mutations such as A1752C/G/T (8.4%), T1753V (18.9%), A1762T (28.7%), G1764A (35.0%) and T1773C (37.1%) were common in the current study.
The mutation of hepatitis B virus and the prognosis of hepatocellular carcinoma after surgery: a pilot study.
PMID: 29628773
2018
Cancer management and research
Result: According to different mutation regions, A1752T/G, T1753C, G1757A, A1762T/G1764A, C1766T, T1768A, A1775G, C1799G, A1846T, T1858C, G1896A, G1898A, G1899A, and Pre S deletion mutations were recognized in 9.8% (39/131), 31.3% (41/131), 42.7% (56/131), 74.0% (97/131), 7.6% (10/131), 5.3% (7/131), 43.5% (57/131), 38.9% (51/131), 35.1% (46/131), 47.3% (62/131), 33.6% (44/131), 17.6% (23/131), 12.2% (16/131), and 16.8% (22/131) cases, respectively (Ta
Phenotypic and Genotypic Shifts in Hepatitis B Virus in Treatment-Naive Patients, Taiwan, 2008-2012.
Method: In addition, we noted a significant decrease in the prevalence of mutation A1752G over the 5-year period (p = 0.022).
Method: Multivariate analysis showed that these 3 changes were not independent (adjusted p = 0.062 for age, 0.067 for male sex, and 0.201 for mutation A1752G; data not shown).
Hepatitis B virus mutations, expression quantitative trait loci for PTPN12, and their interactions in hepatocellular carcinoma.
Result: Of those 19 hotspot mutations, C1653T, T1674C/G, A1703G, G1719T, T1727A/G, T1753C, A1762T, G1764A, G1799C, G1899A, G1915A/C, and C1969T were significantly associated with an increased risk of HCC, whereas C1673T, A1726C, C1730G, and A1752G were significantly associated with a reduced risk of PMID: 25741368
2015
Hepatitis monthly
Table: A1752G
Lower mutation frequency of BCP/precore regions in e antigen-negative chronic HBV-infected children instead of adults patients.
Result: The frequency of the A1752G mutation was higher in genotype B than genotype C HBV (46.1% vs 5.6% in children, 53.0% vs 3.8% in adults, P<0.001 for both).
Result: The ratio of three combined mutations(G1896A/A1762T/G1764A, G1896A/A1846T and G1896A/A1752G)was obviously higher in HBeAg-negative
Table: A1752G
Discussion: Interestingly, the frequency of the A1752G mutation was significantly higher in HBeAg-positive child patients(42.6% vs 27.8%, P<0.05)but was negatively correlated with HBeAg seroconversion.
Hepatitis B virus genotype, mutations, human leukocyte antigen polymorphisms and their interactions in hepatocellular carcinoma: a multi-centre case-control study.
Abstract: Through stepwise regression analysis, HBV genotype, the 11 mutations, HLA-DQ/DR SNPs, and the interaction of rs9272105 with mutation A1752G were all entered into the HCC prediction model, and the area under the curve for the panel including the HLA-DQ/DR SNPs, HBV genotype and mutations was 0.840.
Result: We then used a conditional logistic regression analysis to test the independence of these hotspot mutations and found that the effects of C1653T, C1673T, T1674C/G, C1730G, A1752G, T1753C, A1762T, G1764A, G1899A, G1915A/C<
G1896A Precore Mutation and Association With HBeAg Status, Genotype and Clinical Status in Patients With Chronic Hepatitis B.
Abstract: The basal core promoter mutations detected were A1762T-G1764A (26.9%), C1653T (8.6%), A1752G (10.8%) and C1766T (2.2%).
Result: Among the basal core promoter mutations, A1762T-G1764A double mutation was present in 26.9%, C1653T in 8.6%, A1752G in1 0.8% and C1766T in 2.2% of all isolates.
Table: A1752G
Deep sequencing of hepatitis B virus basal core promoter and precore mutants in HBeAg-positive chronic hepatitis B patients.
Result: Amino acid transitions induced by G1719T, A1726C, A1752G/T and BCP A1762T/G1764A mutants had higher prevalence of 39.7% (23/58), 29.3% (17/58), 27.6% (16/58) and 31.0% (18/58), which mainly occurred in genotype C (21/23), genotype B (16/17), genotype B (13/16) and genotype C (16/18) infection patients, respectively.
Result: In addition, among the twelve hotspots, G1719T and T1753V were significantly associated with genotype C (P < 0.05), while A1726C and A1752G/T were genotype B related (P < 0.05) (Table 2).
HBV mutation literature information.
PMID: 
2021
BMC infectious diseases
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