Abstract: Nucleotide substitution rates were also higher within the medium/low MBL2 production group in all positions described to have an influence in liver cancer development, except for A1499G.
Table: A1499G
Discussion: As for the nucleotide substitution rate, medium/low MBL2 group has higher substitution rate in all investigated positions, except for mutation A1499G where the substitution rate was higher in high MBL2 production group.
Discussion: In an epidemiological study conducted in Hong Kong, A1499G mutation has been associated with the risk of HCC, the data revealed that the mutation rate of A1499 was 20% in chronic HBV patients while it elevated to 62.5% a
Associations between hepatitis B virus mutations and the risk of hepatocellular carcinoma: a meta-analysis.
PMID: 19574418
2009
Journal of the National Cancer Institute
Table: A1499G
Genotype-specific genomic markers associated with primary hepatomas, based on complete genomic sequencing of hepatitis B virus.
Abstract: HCC-related mutations T31C, T53C, and A1499G were associated with HBV subgenotype Ce, and mutations G1613A, G1899A, T2170C/G, and T2441C were associated with HBV subgenotype Cs.
HBV mutation literature information.
PMID: 
2016
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