Result: Three HBV genotype A isolates (358-S; 312-SE; 161-CW) were shown to harbor tyrosine to cysteine substitutions in determinant a residue 100 (Y100C), and the T118V-A128V double mutant was found in three genotype D isolates (Table 2).
Table: A128V
Discussion: The T118V-A128V double mutation was found in three genotype D/ayw3 (subgenotype D2) isolates.
"Molecular analysis of hepatitis B virus ""a"" determinant in asymptomatic and symptomatic Mexican carriers."
Abstract: Mutations identified were Y100N, T126I, Q129H and N146K in the asymptomatic group, and F93I and A128V in the symptomatic group.
Result: Mutations identified in HBV strains from the asymptomatic group were Y100N, T126I, Q129H and N146K; whereas in strains from the symptomatic group identified mutations were F93I and A128V.
Table: A128V
Characterization of naturally occurring and Lamivudine-induced surface gene mutants of hepatitis B virus in patients with chronic hepatitis B in India.
Abstract: The commonest S-gene mutations were T118V and A128V, present in 44 and 38% specimens, respectively.
Abstract: The results of the study, demonstrate (1) clustering of Pre-C and S-gene mutations in the families, (2) horizontal mode of transmission and a common source infection appears to be frequent as evidenced by sequence homology and detailed history, (3) T118V and A128V were the commonest mutations in the S-gene region, while (4) M2 (G1896A) was the commonest pre-C gene mutation, and (5) long-term follow-up evaluation of these mutations suggested.
HBV mutation literature information.
PMID: 
2007
BMC microbiology
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