Result: In addition, the other six mutations types (P127T, A128V, G130E, T131P, M133I and D144N) were not yet identified as VEMs, and D144N was a newly identified mutation (Table 3).
Table:
Discussion: Additionally, a small amount of P127T, A128V, G130E, T131P/N, M133T/I, F134L and D144N mutations was observed in our study, including the less frequent T131N/M133T double mutations.
Occult hepatitis B virus infection in HIV positive patients at a tertiary healthcare unit in eastern India.
Discussion: The presence of sA128V substitution, an immune escape mutation, is often associated with HBV/D2 and is considered as a subgenotype specific change.
HBV quasispecies composition in Lamivudine-failed chronic hepatitis B patients and its influence on virological response to Tenofovir-based rescue therapy.
Result: Among these, only one RT-variant, rtH124N and 6 Result: At 48 week of TDF therapy, the frequencies of rtM204I, rtL80I, sS45A, sT118V, sW196L and sA128V continued to be significantly reduced from baseline in responders, although an increase in frequency of the substitution rtV278I was noted in the HBV clones of the responders during this observational period (Table 5).
The enrichment of HBV immune-escape mutations during nucleoside/nucleotide analogue therapy.
Abstract: Except for the combination of sP120T+sA128V, other double combinations (n=11) were only detected in the NA treatment group, and nine of these combinations in the treatment group were detected in HBV variants without antiviral resistance mutations.
HIV therapy with unknown HBV status is responsible for higher rate of HBV genome variability in Ethiopia.
Abstract: In particular, the 'a' determinant surface gene mutations (sT125S, sA128V, sQ129H/R, sT131I, sC137S, sT143M, sD144D/E, sG145R, sT148P) and the majority of clustered/multiple as well as drug selected immune escape HBsAg mutations were more prevalent
Molecular epidemiology of hepatitis B virus isolated from Bangladesh.
Result: Several mutations were observed in 'a' determinant region of S gene such as, T118V, T125M, T126I, P127T, A128V and T/S143L/M according to different genotypes of HBV (Table 1).
Table: Ala128Val
Discussion: Among which, Thr118Val, Thr125Met, Pro127Thr, Ala128Val and Thr/Ser143Leu/Met were observed in genotype D sequences, which is thought to have strong impacts on functions of S gene.
Molecular epidemiology and genotyping of hepatitis B virus of HBsAg-positive patients in Oman.
Abstract: Furthermore, the frequently occurring mutations in the major hydrophilic loop of the S gene include the T125M, A128V and M133I/L.
Result: Moreover, 93.3% of the HBV/D2 strains had T118V (14/15) whereas all the HBV/D2 isolates were associated with A128V.
Discussion:
Discussion: Several amino acid substitutions within the major hydrophilic loop were observed in our study population which included Y100D, Q101R/H, M103V/I, T125M, A128V, M133L, D144E and G145S.
Hepatitis B surface antigen variants in voluntary blood donors in Nanjing, China.
Hepatitis B virus genotypes and hepatitis B surface antigen mutations in family contacts of hepatitis B virus infected patients with occult hepatitis B virus infection.
PMID: 19207682
2009
Journal of gastroenterology and hepatology
Abstract: A128V & T143M mutations were observed in 5 of 13 (38.4%) subjects and A128V & P127S in 2 of 13 (15.3%) patients (P = 0.385).
Abstract: A128V mutation was seen in two (15.3%) subjects with D2 genotype, while T143M mutation was seen in three (23.07%) subjects with A1genotype.
HBV mutation literature information.
PMID: 
2017
Scientific reports
Browser Board
Co-occurred Entities
Filtrator
ViMRT