literature

HBV mutation literature information.

Mutations in the HBV PreS/S gene related to hepatocellular carcinoma in Vietnamese chronic HBV-infected patients.

PMID: 35390033 2022 PloS one

Table: A128V

Global prevalence and phylogeny of hepatitis B virus (HBV) drug and vaccine resistance mutations.

PMID: 33893696 2021 Journal of viral hepatitis

Result: T118A/R/V, A128V and S/T143L/M had the highest prevalence in genotype D and in Europe, being present >3% of the sequences.

Result: Other VEMs that had an overall prevalence of >1% were T118A/R/V, M133I/L/T, A128V, Q129H/N/R, G145A/R, P120S/T and S/T143L/M (Figure 2A).

Discussion: For example, T118A/R/V, A128V and D144A/E/G/N variants are more common in Europe, which may relate to better vaccine c

Case Report: Application of hepatitis B virus (HBV) deep sequencing to distinguish between acute and chronic infection.

PMID: 33458253 2020 Wellcome open research

Table: A128V

Detection of circulating hepatitis B virus immune escape and polymerase mutants among HBV-positive patients attending Institut Pasteur de Bangui, Central African Republic.

PMID: 31682960 2020 International journal of infectious diseases

Abstract: Potential IEMs sY100C, s

Result: Six of these (sL127I, sA128V, sG130S, sM133T, sF134I, and S140T) were located in the 'a' determinant region, among which three immune escape mutants (IEMs) (sY100C, sA128V, and sM133T) were identified.

Evaluation of the pol/S Gene Overlapping Mutations in Chronic Hepatitis B Patients in Northern Cyprus.

PMID: 31880877 2019 Polish journal of microbiology

Result: The mutation patterns were sI110L + sS193L, sP120L + + sT123N + sT126I + sA128V + sY134H + sD144E + +sG145A, sT118A+sP127T, sI110L+

Identification of a novel tri-genotypic recombinant Hepatitis B virus in Bangladesh.

PMID: 30040979 2018 Virus research

Abstract: Additionally, the complete genome has a frameshift deletion of nine nucleotides from overlapping Surface and Polymerase genes, and a vaccine escape mutation, A128 V, in the surface protein.

Hepatitis B infection among HIV infected individuals in Gabon: Occult hepatitis B enhances HBV DNA prevalence.

PMID: 29315352 2018 PloS one

Method: In addition, we looked for Vaccine Escape Mutants (VEMs) and polymorphic mutations outside (Y100C, Q101H, S117N, T118R and P120S) and within the HBsAg immuno-dominant 'a' determinant (I/T126A/N, A128V, Q129H/R, G130N, M133L/T, K141E, S143L, D144A/H/E and G145R).

Analysis of HBV basal core promoter/precore gene variability in patients with HBV drug resistance and HIV co-infection in Northwest Ethiopia.

PMID: 29408943 2018 PloS one

Table: A128V

Immune-escape mutations and stop-codons in HBsAg develop in a large proportion of patients with chronic HBV infection exposed to anti-HBV drugs in Europe.

PMID: 29859062 2018 BMC infectious diseases

Result: This is the case of sA128V and sP120S selected with higher prevalence in genotype-D than A (sA128V: 3.3%[19/573] vs 0.8%[2/255], P = 0.032; sP120S: 5.1%[29/573] vs 0.8[2/255], P = 0.003).

Figure: Immune-associated escape mutations (sQ101K, sT114R, sP120S/T/A, sT123A/N, sT126N/S, s

Temporal trend of hepatitis B surface mutations in the post-immunization period: 9 years of surveillance (2005-2013) in eastern China.

PMID: 28751727 2017 Scientific reports

Result: In addition, the other six mutations types (P127T, A128V, G130E, T131P, M133I and D144N) were not yet identified as VEMs, and D144N was a newly identified mutation (Table 3).

Table:

Discussion: Additionally, a small amount of P127T, A128V, G130E, T131P/N, M133T/I, F134L and D144N mutations was observed in our study, including the less frequent T131N/M133T double mutations.

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