literature

Differences in HBV Replication, APOBEC3 Family Expression, and Inflammatory Cytokine Levels Between Wild-Type HBV and Pre-core (G1896A) or Basal Core Promoter (A1762T/G1764A) Mutants.

PMID: 23304671 2012 Iranian journal of public health

Abstract: BACKGROUND: To glean insights into the relationship among hepatitis B virus (HBV) genotype/subgenotypes, A1762T/G1764A mutations and advanced liver disease such as liver cirrhosis (LC) and hepatocellular carcinoma (HCC) in Southeast China.

Abstract: Both subgenotype C2 infection and A1762T/G1764A mutations were associated with LC and HCC with cirrhosis, subgenotype C2 (OR=2.033, 95%CI=1.246-3.323, P=0.003 for

PMID: 23346148 2012 Hepatitis monthly

Abstract: RESULTS: Twenty-one patients (52.5%) showed PC G1896A mutation and 11 (27.5%) carried A1762T/G1764A double mutations.

Introduction: Several epidemiological studies have shown that HBV genotype D was predominant in the Tunisian population, and frequencies of double mutation A1762T /G1764A in BCP region and common mutation G1896A in PC region of viral B genome were higher among asymptomatic chronic carriers.

A population-based cohort study for the risk factors of HCC among hepatitis B virus mono-infected subjects in Japan.

PMID: 20820820 2011 Journal of gastroenterology

Abstract: CONCLUSION: HBV mono-infected subjects with A1762T/G1764A double mutation could be at high risk of HCC development during the natural course of HBV infection.

Abstract: Kaplan-Meier method also showed that the probability of HCC occurrence-free was significantly lower in HBV mono-infected subjects with A1762T/G1764A double mutation than those without these mutations.

Abstract: Multivariate-adjusted Cox hazard model showed that A1762T/G1764A (hazard ratio 7.05 [95% confidence interval (CI) 1.03-48.12, P = 0.046]) was the only independent risk factor for the development of

PMID: 20932594 2011 Journal of hepatology

Abstract: 0.02, p = 0.0036) that coincided with the dynamics of quasi-species possessing A1762T mutation.

Association between the various mutations in viral core promoter region to different stages of hepatitis B, ranging of asymptomatic carrier state to hepatocellular carcinoma.

PMID: 20959817 2011 The American journal of gastroenterology

Abstract: A1762T/G1764A had a moderate sensitivity and specificity for HCC.

Abstract: Age, abnormal ALT, HBV DNA (>=10(4) copies/ml), genotype C, C1653T, T1674C/G, T1753V, and A1762T/G1764A were independently associated with HCC compared with those without HCC.

Abstract: Multivariate regression analyses showed that age, male, abnormal alanine aminotransferase (ALT), T1768A, A1762T/G1764A, and A1846T were indep

Characterization of hepatitis virus B isolated from a multi-drug refractory patient.

PMID: 20970466 2011 Virus research

Abstract: A precore stop codon mutation of G1896A and basic core promoter (BCP) mutations A1762T/G1764A were detected in a majority of clones.

A matched case-control study of hepatitis B virus mutations in the preS and core promoter regions associated independently with hepatocellular carcinoma.

PMID: 21108338 2011 Journal of medical virology

Abstract: Multivariate analyses established that genotype C (adjusted odds ratio [AOR] = 3.3; 95% confidence interval [CI] = 1.1-9.8), viral load (>=10(4) copies/ml) (AOR = 2.4; 95% CI = 1.0-5.8), A2962G (AOR = 18.7; 95% CI = 7.5-46.7), preS2 start codon mutation (AOR = 12.5; 95% CI = 3.4-45.5), C105T (AOR = 0.1; 95% CI = 0.0-0.2), T1753V (AOR = 3.1; 95% CI = 1.1-9.2), and A1762T/G1764A (AOR = 2.9; 95% CI = 1.1-7.3) were associated independently with HCC, adjusted for factors including mutations in both regions.

The clinical implications of hepatitis B virus genotype: Recent advances.

PMID: 21199523 2011 Journal of gastroenterology and hepatology

Abstract: HBV genotype C has a higher frequency of basal core promoter (BCP) A1762T/G1764A mutation, pre-S deletion and is associated with higher viral load than genotype B.

Abstract: Similarly, genotype D has a higher prevalence of BCP A1762T/G1764A mutation than genotype A.

Viral factors and outcomes of chronic HBV infection.

PMID: 21212756 2011 The American journal of gastroenterology

Abstract: The most common core promoter mutations involve a double substitution A1762T and G1764A (TA).

Natural history of chronic hepatitis B REVEALed.

PMID: 21323729 2011 Journal of gastroenterology and hepatology

Abstract: A significant association with risk of cirrhosis and HCC was also observed for HBV genotype, precore G1896A mutant and basal core promoter A1762T/G1764A double mutant.